TRITIUM NMR ANALYSIS OF ART817: METASTIC MELANOMA & PROTEIN KINASE C

受试者的化合物被标记为Rotenberg博士的氚 与美国放射性标记化合物公司签订了一份小型合同 Business，ARC，Inc.缺乏进行氚核磁共振的资源 标签产品的分析。这种核磁共振研究证实了 氚标签的位置和级别，作为质量的最后一步 为像Rotenberg博士这样的客户提供保证。氚和质子核磁共振 仅限分析。蛋白激酶C(PKC)是一种钙离子， 磷脂依赖的蛋白激酶是一种重要的 正常的促生长信号通路。一种抗肿瘤药物地奎宁 在几种动物模型中，药物已被证明能抑制PKC活性 无论是在体外还是在细胞内。因为膜水平的PKC活性具有 与黑色素瘤细胞的转移活性有关，这 系统提供了一个重要的模型，在其中1)研究 新的PKC抑制剂和PKC亚型反义试剂，以及2) 探讨PKC在肿瘤转移机制中的意义。用户 详细信息：实验详细信息：用户编号：1712核磁共振城市，州： 纽约州法拉盛1天资金来源：州立(大学)资金1 复合费用：236.91美元计划收入：236.91美元(预计)

The subject compound was tritium labelled for Dr. Rotenberg under contract at American Radiolabelled Compounds, Inc. As a small business, ARC, Inc. lacks the resources to conduct tritium NMR analyses of labelled products. Such NMR studies serve to confirm the site and level of tritium labelling, as a final step in the quality assurance for customers such as Dr. Rotenberg. Tritium and proton NMR analyses only. Protein kinase C (PKC) is a Ca(2+) and phospholipid-dependent protein kinase that is a vital component in normal growth-promoting signal pathways. Dequalinium, an anti-tumor agent in several animal models, has been shown to inhibit PKC activity both in vitro and in cells. Because membrane-level PKC activity has been implicated in the metastatic activity of melanoma cells, this system offers an important model in which 1) to study the effect of new PKC inhibitors and PKC isoform anti-sense reagents, and 2) to probe the significance of PKC in the mechanism of metastasis. User Details: Experiment Details: User Number: 1712 NMR City, State: Flushing, NY 1 day Funding Source: State (University) Funds 1 compound Charge: $236.91 Program Income: $236.91 (projected)