ANALYSIS OF MORPHOMETRIC VARIABILITY AN APPLICATION OF PARALLEL PROCESSING

淋球菌引起的疾病是一种重要的 全球性的公共卫生问题。成功管理的关键 这种疾病的特征是定义了使淋球菌成为 人类病原体。淋球菌的繁殖能力是 依赖于获得生长必需的铁。扣留铁的方法 脊椎动物宿主是非特异性免疫的主要机制 抗感染。因此，表达了一种高亲和力 铁摄取系统是感染的先决条件。一个中环 淋球菌获取铁的过程中的成分是 周质铁结合蛋白，FBP。为了更清楚地阐明 淋球菌铁获得的分子基础，我们打算研究 与FBP相关的方面，它将具体定义其在 机制和利用是定义其他分子的探针 这一进程的参与者。我们研究的一个重要组成部分 涉及使用计算机设施，这将促进(1) 核酸和蛋白质序列的存储和分析(2) 数据库搜索序列和结构基序，(3)分子 建模；(4)大量数据的统计分析。在……里面 此外，结果的图形化显示对于数据分析很重要 和展示。

Disease caused by Neisseria gonorrhoeae is a significant world-wide public health problem. A key to the successful management of this disease is defining the attributes which make the gonococcus a human pathogen. The ability of the gonococcus to multiply is dependent upon obtaining growth-essential iron. Withholding iron by vertebrate hosts is a principal mechanism of non-specific immunity against infection. Thus, the expression of a high-affinity iron-acquisition system is a prerequisite for infection. A central component in the process of iron acquisition by gonococci is the periplasmic iron-binding protein, Fbp. To more clearly elucidate the molecular basis of gonococcal iron-acquisition, we intend to study aspects related to Fbp which will specifically define its role in this mechanism and exploit is as a probe to define other molecular participants of the process. An essential component of our studies involves the use of computing facilities which will facilitate (1) the storage and analysis of nucleic acid and protein sequences, (2) database searches for sequences and structural motifs, (3) molecular modeling, and (4) statistical analysis of large amounts of data. In addition, graphical display of results is important for data analysis and presentation.