MOLECULAR MECHANISM OF GENOMIC IMPRINTING: TUMOROGENIC PHENOTYPES

我感兴趣的是了解一个分子的基础 称为基因组印迹的非孟德尔遗传形式。这是一个 哺乳动物中区别于亲本的基因调控类型 常染色体等位基因的起源。这样做的效果是让人沉默 亲本等位基因，并激活印记基因座上的另一个等位基因。 这类调控过程(染色体不平衡， 易位和其他突变)会导致发育异常或 致瘤表型。区分事件在中启动 发育或致瘤表型。与众不同的事件 是在亲代生殖系中启动的，可能是表观遗传的 派生的标记或印记，然后传输到 后代。这项研究的目的是了解 印迹的分子性质，印迹如何稳定和 忠实地传递给胚胎，以及这些最终是如何影响 转流活动。这些信息将改善我们的 对正常发展的理解，以及我们对 细胞转化中的分子事件。

I am interested in understanding the molecular basis of a non-Mendelian form of inheritance called genomic imprinting. It is a type of gene regulation in mammals that distinguishes the parental origin of autosomal alleles. The effect of this is to silence parental allele and activate the other allele at an imprinted locus. This type of regulatory process (chromosomal imbalances, translocation, and other mutations) result in abnormal development or tumorigenic phenotypes. The distinguishing events are initiated in the development or tumorigenic phenotypes. The distinguishing events are initiate in the parental germ lines, probably as epigentically derived markings or imprints, that are then transmitted to the offspring. The objectives of this research are to understand the molecular nature of the imprint, how the imprints are stably and faithfully transmitted to the embryo, and how these ultimately affect transriptional activity. This information will improve our understanding of normal development, as well as our understanding of molecular events in cellular transformation.