MR IMAGING CONTRAST ENHANCEMENT BASED ON INTERMOLECULAR ZERO QUANTUM COHERENCES

这项协作工作是由 资助猴子研究(RO1 NS17413-20，7/1/96-6/30/2001)。 它以协同的方式与类似的和 将与人类进行平行实验，使用。这位将军 本研究的目的是了解神经机制。 潜在的实践，即复杂的、有目的的运动动作；这些 机制在很大程度上是未知的。在猴子研究中，恒河猴 受过训练以执行通常用于确定存在的任务 对脑损伤患者的结构性失用的研究，包括 复制简单的几何图形，将对象组装在 零部件，以及迷宫中的路线寻找。单人的活跃性 任务执行过程中的细胞被记录在 猴脑使用7个微电极系统。我们已经开始了 在人类受试者中使用4特斯拉的fMRI检查哪些区域 在相同或相似的任务期间被激活。广泛的初步 已经收集的数据表明，活动主要是在 额叶皮质，这是一个出乎意料的发现。

This collaborative effort is an extension of work supported by a grant funded for monkey studies (RO1 NS17413-20, 7/1/96 - 6/30/2001). It is conducted in a synergistic fashion together with similar and parallel experiments to be carried out with humans using. The general goal of this research is to understand the neural mechanisms underlying praxis, that is complex, purposeful motor actions; these mechanisms are largely unknown. In the monkey studies, rhesus monkeys are trained to perform tasks commonly used to determine the presence of constructional apraxia in brain-damaged human patients, including copying simple geometrical figures, assembling objects out of component parts, and route finding in a maze. The activity of single cells during task performance is recorded in key cortical areas of the monkey brain using a 7-microelectrode system. We have started examining in human subjects using fMRI at 4 Tesla which regions are activated during identical or analogous tasks. Extensive preliminary data has been collected demonstrating that activity is primarily in the frontal cortex, a finding that was unexpected.