HALF FOV METHOD FOR CINE IMAGING

介绍：我们的小组正在研究的神经基板的 情绪、心境和气质在健康志愿者和 情绪障碍 我们特别感兴趣的是探索 不同情感体验的大脑伴随物以及 心境障碍中这种过程的中断与临床 因素，如症状概况，病程，和反应， 躯体疗法 我们假设皮质下（前部） 边缘）处理器有助于调解原始，快速 反应，以行动为导向的情感体验，称为情绪， 上覆的（前额叶）新皮层处理器有助于 调解更精细化、更持续化、认知化 情感体验也就是情绪 之间的交互 皮层下情绪和新皮层情绪处理器可能有助于 调解的综合性，持久的调节的情感基调 被称为气质。 方法：我们使用正电子发射 断层扫描（PET）和磁共振波谱（MRS）来探索 脑葡萄糖代谢和生化在休息和 情感（短暂的自我诱导悲伤）激活。 我们也 使用结构磁共振成像（MRI）评估大脑 体积和皮质下高信号。 结果/结论：我们 特别感兴趣的是检测基线功能性大脑 对精神药物的后续反应的标志。 如果 如果成功，这种技术可以更有效地瞄准 难治性情绪障碍患者的治疗。

Introduction: Our group is investigating the neural substrates of emotion, mood, and temperament in healthy volunteers and patients with mood disorders. We are particularly interested in exploring the cerebral concomitants of varying affective experiences and how disruptions of such processes in mood disorders relate to clinical factors such as symptom profile, course of illness, and responses to somatic therapies. We hypothesize that a subcortical (anterior paralimbic) processor contributes to mediation of primitive, rapid response, action-oriented affective experiences known as emotions, and that an overlying (prefrontal) neocortical processor contributes to mediation of more refined, more sustained, cognition-oriented affective experiences known as moods. Interactions between the subcortical emotional and neocortical mood processors may contribute to mediation of integrative, enduring modulation of affective tone known as temperament. Methods: We are using positron emission tomography (PET), and magnetic resonance spectroscopy (MRS) to explore cerebral glucose metabolism and biochemistry at rest and during affective (transient self-induced sadness) activation. We are also using structural magnetic resonance imaging (MRI) to assess cerebral volumes and subcortical hyperintensities. Results/Conclusions: We are particularly interested in detecting baseline functional cerebral markers of subsequent responses to psychotropic agents. If successful, such techniques could allow more effective targeting of therapies in patients with refractory mood disorders.