MULTIDISCIPLINARY BASIC RESEARCH TRAINING IN CANCER

（申请人描述）：A.目的和项目特点-该项目旨在为希望从事癌症病理生物学基础研究的个人提供博士后培训。该计划旨在实现最大的教师参与，并特别努力培养癌细胞生物学，癌症诊断和癌症治疗之间界面的工作知识。申请人的目标是培养高度专注的独立研究人员，能够与其他基础科学家以及参与癌症研究和治疗的临床同事进行富有成效的合作。实现这一目标的主要手段是建立一个互动的多学科研究团队，一个正式的肿瘤生物学课程，将细胞生长控制的当前概念与人类癌变的概念结合起来，以及每周一次的研讨会，在这个研讨会上，受训者与其他受训者、培训资助团队成员以及梅奥科学界广泛讨论他们的研究。（二）研修生：每5年招收9名博士后研修生。持有博士和/或医学博士学位的个人符合条件，并根据学业成绩，研究经验，职业目标，推荐信和学术研究动机进行选择。C.培训设施-个别调查人员的研究实验室是主要的培训设施。这些实验室位于生物化学和分子生物学、免疫学、药理学、发育肿瘤学研究、泌尿学研究、实验病理学和实验室医学以及胸部疾病研究的院系/分部。这些部门/部门都位于古根海姆基础生物医学研究大楼内，并得到机构共享研究资源设施的支持，包括分析核磁共振、电子显微镜、质谱、分子生物学、放射免疫测定、药理学、癌症生物统计学、生物医学成像、流式细胞术/光学形态测定、数学方法、蛋白质测序/肽合成、研究计算、细胞遗传学和病理学。动物住房、工程、教室和演讲空间都有单独的设施。

DESCRIPTION (Applicant's Description): A. Purpose and Program Characteristics - The purpose of this program is to provide postdoctoral training to individuals wishing to pursue basic research in the pathobiology of cancer. The program is designed to achieve maximum faculty participation and specifically strives to foster a working knowledge of the interface between cancer cell biology, cancer diagnostics, and cancer therapy. The applicants' goal is to produce highly focused independent investigators capable of productive collaboration with other basic scientists and with clinical colleagues involved in the study and treatment of cancer. T h e p rimary means of achieving this goal are an interactive and multidisciplinary research faculty, a formal Tumor Biology Curriculum which integrates current concepts in cell growth control with those of human carcinogenesis, and a weekly workshop in which trainees discuss their research with fellow trainees, with members of the training grant faculty, and with the Mayo scientific community at large. B. Trainees - Nine postdoctoral trainees are requested to participate for each of five years. Individuals holding the Ph.D. and/or M.D. degrees are eligible and are selected on the basis of academic record, research experience, career goals, letters of recommendation, and motivation for academic research. C. Training Facilities - The research laboratories of individual investigators constitute the primary training facilities. These are located within the Departments/Divisions of Biochemistry and Molecular Biology, Immunology, Pharmacology, Developmental Oncology Research, Urology Research, Experimental Pathology, and Laboratory Medicine, and Thoracic Diseases Research. These Departments/Divisions are all located within the Guggenheim Building for Basic Biomedical Research and are supported by institutional Shared Research Resource Facilities in Analytical NMR, Electron Microscopy, Mass Spectroscopy, Molecular Biology, Radioimmunoassay, Pharmacology, Cancer Biostatistics, Biomedical Imaging, Flow Cytometry/Optical Morphometry, Mathematical Methods, Protein Sequencing/Peptide Synthesis, Research Computing, Cytogenetics, and Pathology. Separate facilities are available for animal housing, engineering, and classroom and lecture space.