Multidisciplinary training in basic and translational Alzheimer's disease research

项目总结/摘要 这个新的应用程序的机构T32计划的目的是提供先进的翻译 阿尔茨海默病和AD相关痴呆症（ADRD）的研究培训。这一建议建立 UCSD优秀的研究和培训环境以及参与的邻近地区 机构（索尔克研究所，桑福德-伯纳姆-普雷比斯研究所和斯克里普斯研究所 研究所）以及利用加州大学圣地亚哥分校阿尔茨海默病研究中心的资源， AD合作研究和其他附属项目。利用这个独特的 我们的研究社区的机会，我们将提供重点，但也多学科 培训四名博士前和四名博士后（MD，PhD或MD/PhD）学员的方法， 应对人口老龄化带来的ADRD挑战。该计划有三个关键 特点：1.学术桥梁-一个主要的重点将是提供博士前学生 和博士后研究员的概念和必要的研究工具，以解决问题， ADRD研究中的基础、转化和临床问题的接口。这座桥将是 反映在参与教师的不同兴趣和专业知识， 培训计划本身，包括正式的教学， 教学和不太正式的研讨会，期刊俱乐部，与教师的互动会议，以及科学 退2.多学科方法-就其本质而言，神经科学是一个多学科的 调查领域。培训教师带来了这个程序的专业知识，经验， 在各种方法和学科的技术知识。我们的目标是培养未来 调查人员必须在其中几个领域有效地工作和思考。完成这项工作的方法是 通过选择最好的教师，通过汇集学员和导师谁是开放的， 跨学科交流思想和方法，并为他们提供一个指导论坛， 讨论和互动。此外，我们希望吸引到ADRD社区教师 最近将研究工作扩展到ADRD或具有以下专业知识的成员 相关领域或技术，可以扩大ADRD的研究范围。3.导师制- 为该培训方案提出的一个不可分割的方面是对导师制的关注。此外 向受训者自己的研究导师/主管，每个受训者将选择一个共同赞助者， 为他/她的研究提供更多的多学科投入和监督。初级教员 还将从培训计划执行委员会中选出一名导师， 提供建议和支持，以推进他们的学术轨迹，并提高 实验室实习生的成功。

PROJECT SUMMARY/ABSTRACT This new application for an institutional T32 program is designed to provide advanced translational research training on Alzheimer's disease and AD related dementias (ADRD). This proposal builds on the outstanding research and training environment of UCSD and participating neighboring institutions (The Salk Institute, Sanford-Burnham-Prebys Institute, and The Scripps Research Institute) as well as leveraging the resources of the UCSD Alzheimer's Disease Research Center, the AD Collaborative Study, and other affiliated programs. To take advantage of the unique opportunities of our research community, we will offer focused but also multidisciplinary approaches to training four pre- and four postdoctoral (MD, PhD, or MD/PhD) trainees to prepare them to tackle the challenges of ADRD due to population aging. The program has three key features: 1. Academic bridging - A principal focus will be to provide the predoctoral students and postdoctoral fellows with concepts and research tools necessary to address issues at the interfaces of basic, translational, and clinical questions in ADRD research. This bridging will be reflected in the diverse interests and expertise of the participating faculty, the nature of the projects proposed by the trainees, and the training plan itself which includes formal didactic teaching and less formal seminars, journal clubs, interactive sessions with faculty, and scientific retreat. 2. Multidisciplinary Approach - By its very nature, neurosciences is a multidisciplinary field of investigation. The training faculty brings to this Program expertise, experience, and technical knowledge in a variety of approaches and disciplines. Our goal is to train future investigators who are to work and think effectively in several of these areas. This will be achieved by choosing the best faculty, by bringing together trainees and mentors who are open to interdisciplinary exchange of ideas and approaches, and providing them a forum for instruction, discussions, and interactions. In addition, we hope to draw into the ADRD community faculty members who have recently expanded their research efforts into ADRD or who have expertise in related areas or in technologies that can expand the scope of ADRD research. 3. Mentorship – An integral aspect proposed for this Training Program is the attention to mentorship. In addition to the trainee's own research mentor/supervisor, each trainee will select a co-sponsor chosen to provide more multidisciplinary input and oversight into his/her research. Junior faculty members will also be assigned a mentor chosen from the Executive Committee of the Training Program to provide advice and support in order to advance their academic trajectory and enhance the success of their laboratory trainees.