Multidisciplinary training in basic and translational Alzheimer's disease research

项目摘要/摘要 这一针对机构T32计划的新应用程序旨在提供高级翻译 关于阿尔茨海默病和阿尔茨海默病相关痴呆的研究培训。这项建议建立了 UCSD及其周边地区优秀的科研训练环境 机构(索尔克研究所、桑福德-伯纳姆-普雷比研究所和斯克里普斯研究所 研究所)以及利用加州大学圣迭戈分校阿尔茨海默病研究中心的资源， AD协作性研究和其他附属计划。利用独一无二的 利用我们研究界的机遇，我们将提供专注的、多学科的 培训4名博士后和4名博士后(MD、PhD或MD/PhD)学员的方法 他们应对由于人口老龄化而带来的ADRD挑战。该计划有三个关键 特点：1.学术衔接-主要重点将是为博士前学生提供 和博士后研究员，拥有必要的概念和研究工具，以解决 ADRD研究中基础、翻译和临床问题的接口。这一桥梁将是 反映在参与的教员的不同兴趣和专业知识中， 学员提出的项目和培训计划本身，其中包括正式的教学内容 教学和不太正式的研讨会、期刊俱乐部、与教员的互动会议和科学 撤退。2.多学科方法--神经科学本质上是一门多学科 调查领域。培训教师为该计划带来专业知识、经验和 掌握各种方法和学科的技术知识。我们的目标是培养未来 调查人员将在这些领域中的几个领域有效地工作和思考。这将会实现的 通过选择最好的教职员工，通过将学员和导师聚集在一起 跨学科交流思想和方法，并为他们提供一个指导的论坛， 讨论和互动。此外，我们希望吸引ADRD社区教职员工 最近将他们的研究努力扩展到ADRD或具有以下专业知识的成员 在相关领域或可以扩大ADRD研究范围的技术方面。3.导师制-- 这项培训计划的一个重要方面是重视导师关系。此外 对于学员自己的研究导师/主管，每个学员将选择一位共同赞助人来选择 为他/她的研究提供更多多学科的投入和监督。初级教员 还将从培训计划执行委员会中挑选一名导师，以 提供建议和支持，以推动他们的学业轨迹，并提高 他们实验室实习生的成功。

PROJECT SUMMARY/ABSTRACT This new application for an institutional T32 program is designed to provide advanced translational research training on Alzheimer's disease and AD related dementias (ADRD). This proposal builds on the outstanding research and training environment of UCSD and participating neighboring institutions (The Salk Institute, Sanford-Burnham-Prebys Institute, and The Scripps Research Institute) as well as leveraging the resources of the UCSD Alzheimer's Disease Research Center, the AD Collaborative Study, and other affiliated programs. To take advantage of the unique opportunities of our research community, we will offer focused but also multidisciplinary approaches to training four pre- and four postdoctoral (MD, PhD, or MD/PhD) trainees to prepare them to tackle the challenges of ADRD due to population aging. The program has three key features: 1. Academic bridging - A principal focus will be to provide the predoctoral students and postdoctoral fellows with concepts and research tools necessary to address issues at the interfaces of basic, translational, and clinical questions in ADRD research. This bridging will be reflected in the diverse interests and expertise of the participating faculty, the nature of the projects proposed by the trainees, and the training plan itself which includes formal didactic teaching and less formal seminars, journal clubs, interactive sessions with faculty, and scientific retreat. 2. Multidisciplinary Approach - By its very nature, neurosciences is a multidisciplinary field of investigation. The training faculty brings to this Program expertise, experience, and technical knowledge in a variety of approaches and disciplines. Our goal is to train future investigators who are to work and think effectively in several of these areas. This will be achieved by choosing the best faculty, by bringing together trainees and mentors who are open to interdisciplinary exchange of ideas and approaches, and providing them a forum for instruction, discussions, and interactions. In addition, we hope to draw into the ADRD community faculty members who have recently expanded their research efforts into ADRD or who have expertise in related areas or in technologies that can expand the scope of ADRD research. 3. Mentorship – An integral aspect proposed for this Training Program is the attention to mentorship. In addition to the trainee's own research mentor/supervisor, each trainee will select a co-sponsor chosen to provide more multidisciplinary input and oversight into his/her research. Junior faculty members will also be assigned a mentor chosen from the Executive Committee of the Training Program to provide advice and support in order to advance their academic trajectory and enhance the success of their laboratory trainees.