WOMENS POOLING PROJECT

描述 (根据申请者摘要改编)Lori Mosca博士是一名初级教员 密歇根大学心脏病学系成员 最近完成了NRSA预防心脏病学和 1996年5月在哥伦比亚大学获得流行病学博士学位。 在过去的两年里，她一直积极参与发起 妇女共享项目，该项目的建立是为了解决关键的 需要了解有关女性心血管危险因素和疾病的信息。 WPP的目标是将过去40年从 在美国的长期社区研究，目的是 检查女性的健康问题，这些问题不能在 单一研究。WPP是一项历史前瞻性研究，具有很好的 以近100%的随访、大量和种族特征为特征的队列 多样性。将通过汇集以下数据来检查女性的心血管风险 来自查尔斯顿心脏研究的12000多名年龄在30-79岁之间的女性 埃文的县研究，弗雷明翰心脏研究，兰乔·贝尔纳多研究， 圣安东尼奥心脏研究和特库姆塞社区健康研究。这个 WPP包括年龄、血压、胆固醇、 糖尿病、体重指数、吸烟方式、教育水平和 心电图仪的发现。一项由NHLBI赞助的试点研究 证明了从上述队列中汇集数据是可行的。初步 结果表明，在负担方面， WPP中种族亚群的心血管危险因素。这个 传统心血管疾病(CVD)危险因素和 它们与全因死亡率、心血管疾病和冠心病的关系 疾病(CHD)将在总体上和按种族确定。建议数 研究还将评估每个队列中相应的男性数据，并 将考察心血管危险因素负担的性别差异 关于各种原因、心血管疾病和冠心病的死亡率。这项研究将产生 有关女性心血管风险的及时数据及其与 可能有助于制定适当的预防策略的男性 不同的人群。莫斯卡博士将根据 米利森·希金斯博士的指导，国际公认的 心血管流行病学家。这一奖项的目标将是发展 莫斯卡博士成为一名独立的研究人员，这样她就能够 对心血管流行病学领域的贡献，特别是在 妇女健康领域。(摘要结束)

DESCRIPTION (Adapted from applicant's abstract) Dr. Lori Mosca is a Junior faculty member in the Division of Cardiology at the University of Michigan who recently completed an NRSA training program in Preventive Cardiology and received her Ph.D. in Epidemiology from Columbia University in May, 1996. Over the past two years she has been actively involved in the initiation of The Women's Pooling Project, which was established to address the critical need for information about cardiovascular risk factors and disease in women. The goal of the WPP is to combine data collected over the past 40 years from long term, community-based studies in the United States, for the purpose of examining health issues in women that cannot be adequately addressed in a single study. The WPP is a historical prospective study which has well characterized cohorts with nearly 100% follow-up, large numbers and ethnic diversity. Cardiovascular risk in women will be examined by pooling data on over 12,000 women aged 30 - 79 years from the Charleston Heart Study, the Evan's County Study, the Framingham Heart Study, the Rancho Bernardo Study, the San Antonio Heart Study, and the Tecumseh Community Health Study. The WPP includes risk factors such as age, blood pressure, cholesterol, diabetes, body mass index, smoking pattern, educational level, and electrographic findings. An NHLBI sponsored pilot study was conducted that demonstrated pooling data from the above cohorts was feasible. Preliminary results suggest there are striking differences in the burden of cardiovascular risk factors among ethnic subgroups in the WPP. The prevalence of traditional cardiovascular disease (CVD) risk factors and their relation to mortality due to all causes, CVD and coronary heart disease (CHD) will be determined overall and by ethnic group. The proposed study will also evaluate the corresponding male data from each cohort and will examine gender differences in the burden of cardiovascular risk factors on mortality due to all causes, CVD and CHD. This study will generate timely data regarding cardiovascular risk in women and how it differs from men that may be useful for developing appropriate preventive strategies for diverse populations. Dr. Mosca will conduct the proposed research under the guidance of Dr. Millicent Higgins, an internationally recognized Cardiovascular Epidemiologist. The goal of this award will be to develop Dr. Mosca into an independent researcher so that she will be able to make contributions to the field of Cardiovascular Epidemiology, specifically in the area of Women's Health. (End of Abstract)