INTERGENERATIONAL TRANSMISSION--SUBSTANCE ABUSE

本次高级科学家奖（K 05）申请的总体目标 为候选人提供一段稳定的资金， 对发展中国家进行全职方案研究 生物行为因素的家庭传播模式， 导致行为偏差的代际表现 物质使用障碍（Substance Use Disorders，SUD） 新兴学科 发展性精神病理学试图阐明病因， 过程，以及SUD、品行障碍等条件的后遗症 (CD)反社会人格障碍（ASPD） 整合多学科知识，如心理学， 精神病学、遗传学、流行病学和神经科学， 发展导向 基础研究人员和理论家 假设关键的发展时期存在， 家庭或独特的环境因素是最有影响力的， 确定不利的精神病理学表型。 有限 已经对关键的 CD、ASPD和SUD病因的发展阶段，但 这些信息对于有效的时间安排和性质至关重要， 有针对性的药物滥用预防干预措施。 拟议程序 调查的目的是进行系统的前瞻性研究， 传染性和非传染性的性质和预测因素 行为异常、物质使用和SUD的发育风险 从青春期前开始， 从童年到青春期和青年期的过渡。 的 研究还将检查可传播的 影响。 性别异质性的存在是合理的，因为 已经描述了在相同- 外化行为的性-父母-子女传播。 的 研究结果对预防药物滥用具有重要意义。

The overarching goal of this Senior Scientist Award (K05) application is to provide the candidate with a period of stable funding in which to conduct full-time programmatic research on the developmental patterning of familial transmission of biobehavioral factors that contribute to the transgenerational manifestations of conduct deviation and substance use disorders (SUD). The emerging discipline of developmental psychopathology attempts to elucidate the etiology, course, and sequelae of conditions such as SUD, Conduct Disorder (CD), and Antisocial Personality Disorder (ASPD) through the integration of knowledge from multiple disciplines such as psychology, psychiatry, genetics, epidemiology and neuroscience within a developmental orientation. Basic researchers and theorists have posited that critical developmental periods exist when particular familial or unique environmental factors are most influential in determining an adverse psychopathological phenotype. Limited research has been conducted on the presence and timing of critical developmental periods in the etiology of CD, ASPD and SUD, yet such information is vital to the efficacious timing and nature of targeted drug abuse prevention interventions. The proposed program of investigation aims to undertake systematic prospective research into the nature and predictors of transmissible and non-transmissible developmental risk for conduct deviancy, substance use and SUDs beginning in the prepubertal period and continuing across the transition from childhood to adolescence and young adulthood. The research will also examine sex heterogeneity of transmissible influences. The existence of sex heterogeneity is plausible since differential transmission effects have been described between same- sex-parent to child transmission for externalizing behaviors. The results have important implications for drug abuse prevention.