DIFFERENTIAL METABOLISM OF DIETARY FATTY ACIDS

描述：初步数据表明，油酸氧化的速率是 与棕榈酸相比增加了21%。如果OA与PA的比例在 如果饮食增加，进食状态下总脂肪酸氧化率 也可能增加;因此，每日脂肪平衡可能会减少人类喂养 富含OA的饮食。这将对治疗和 预防肥胖。间接量热法将在美联储和 在34名年轻健康的成年人中进行空腹状态研究， 条件：30天后，固体食物饮食（“磨合期”），并再次， 30-日配方饮食。受试者将随机接受以下治疗： 与固体食物饮食相似的对照配方（OA=PA= 16.4%总kcal） 或高油酸配方（OA= 31.4%kcal; PA= 1.7%kcal）。使用 双能X射线吸收测定法，在 吃完配方奶后主要研究者（PI）将讨论四个问题 具体目标。在具体目标1中，PI将确定是否需要更高的 油酸（以及棕榈酸的摄入量较低）与 脂肪氧化率更高PI假设脂肪的比率 进食状态下的氧化（g/hr），针对 固体食物饮食的脂肪氧化率，将更高（30%）， 这些受试者被随机分配到富含OA的饮食组，与对照组相比。在 具体目标2，PI将测量维持恒定所需的能量摄入 在每次饮食期间测量体重，并测量无脂肪质量和脂肪质量， 每次饮食变化后。私家侦探推测高脂肪率 高OA饮食的氧化将与较高的能量摄入有关 维持恒定的体重。在具体目标3中，PI将 将液体配方饮食上的脂肪氧化与 固体食物饮食。PI假设脂肪氧化会增加， 喂养富含OA的饮食。在具体目标4中，PI将测量 在固体食物和配方饮食期间喂养的影响。的PI 假设高OA喂养将与较高的体温相关， 喂养的效果。

DESCRIPTION: Preliminary data indicate that the rate of oleic acid oxidation is 21 percent increased compared to palmitic acid. If the ratio of OA to PA in the diet were to increase, the rate of total fatty acid oxidation in the fed state also may increase; thus, daily fat balance might be decreased in humans fed diets enriched in OA. This would have significance to the treatment and prevention of obesity. Indirect calorimetry will be performed in the fed and fasting state in 34 young, healthy adults who will be studied under two conditions: after a 30-day, solid food diet ("run-in phase") and again, after a 30-day formula diet. The subjects will be randomized to receive either a Control Formula similar to the solid food diet (OA=PA=16.4 percent total kcal) or a High Oleic Acid Formula (OA=31.4 percent kcal; PA=1.7 percent kcal). Using dual-energy x-ray absorptiometry, body composition will be monitored before and after the formula diet. The principal investigator (PI) will address four specific aims. In specific aim 1, the PI will determine if a higher intake of oleic acid (and a reciprocally lower intake of palmitic acid) is associated with a higher rate of fat oxidation. The PI hypothesizes that the rate of fat oxidation (g/hr) in the fed state, adjusted for the covariate effect of the rate of fat oxidation on the solid food diet, will be higher (30 percent) in those subjects randomized to the OA-enriched diet compared to controls. In the specific aim 2, the PI will measure energy intake required to maintain constant body weight during each diet and to measure fat-free mass and fat mass, before and after each dietary change. The PI hypothesizes that a higher rate of fat oxidation on the high OA diet will be associated with a higher energy intake required to maintain constant body weight. In specific aim 3, the PI will compare fat oxidation on the liquid formula diet with that observed on the solid food diet. The PI hypothesizes that fat oxidation will increase in those fed the OA-enriched diet. In specific aim 4, the PI will measure the thermic effect of feeding during both the solid food and formula diet periods. The PI hypothesizes that the high OA feeding will be associated with a higher thermic effect of feeding.