TOBACCO CRAVING AND DEPENDENCE IN 2 SUBTYPES OF SMOKERS

描述：（申请人摘要） 这项修订后的研究项目的长期目标是研究 在恢复多种物质中烟草渴望和依赖的差异 使用者与无其他依赖/滥用史的吸烟者相比， 开发有效戒烟治疗方法的初步步骤 在这些人群中，他们的健康受到多种因素的协同影响， 危险因素 具体目标包括：1）评估烟草渴望 吸烟者的2个亚型之间; 2）评估烟草依赖的2 吸烟者的亚型; 3）确定尼古丁偏好的差异 最后，（4）探讨群体之间的关系。 渴望、药物依赖史和尼古丁自我给药。 的 最初提出的大型研究已大幅修改;两个较小的 我们现正进行研究，以回应检讨者的关注。 基于实验室的评估将在最先进的人体中进行 行为药理学范式 每项评估都表明， 心理测量的可靠性 在第一项研究中，受试者完成了对烟草的渴望， 在烟草剥夺和非剥夺条件下的依赖措施。 自我报告的依从性通过实验者的观察得到验证， 生化测量 在第二项研究中，受试者接受尼古丁 自我给药试验，该试验方案先前已在 剥夺目前吸烟者无意戒烟（休斯，斯特里克勒等 等人，1989）。 这些数据将是第一批研究 实验室中不同亚型吸烟者的烟草渴求和依赖 设置.

DESCRIPTION: (Applicant's Abstract) The long term objective of this revised research project is to examine differences in tobacco craving and dependence in recovering polysubstance users versus smokers without a history of other dependence/abuse as a initial step towards developing effective treatments for smoking cessation in these populations whose health is synergistically compromised by multiple risk factors. Specific aims include: 1) assessment of tobacco craving among 2 subtypes of smokers; 2) assessment of tobacco dependence among 2 subtypes of smokers; 3) determination of differences in nicotine preference among groups; and finally, 4) exploration of the relationship between craving, history of drug dependence and nicotine self administration. The large study originally proposed has been substantially modified; two smaller studies will now be conducted to address the reviewers' concerns. Laboratory based assessments will be conducted in a state-of-the-art human behavioral pharmacology paradigm. Each assessment has demonstrated psychometric soundness. In study one, subjects complete tobacco craving and dependence measures under tobacco deprived and non-deprived conditions. Self-reported compliance is validated by experimenter observations and biochemical measurement. In study two, subjects undergo a nicotine selfadministration trial in a protocol that was previously validated in deprived current smokers with no intention to quit (Hughes, Strickler, et al, 1989). These data will be among the first to examine differences in tobacco craving and dependence among subtypes of smokers in a laboratory setting.