Development and validation of a latent tuberculosis diagnostic

在全球范围内，结核病是导致死亡的主要原因，2014年有960万例新诊断。潜伏性结核感染的诊断很重要，但由于目前的检测方法不够理想，因此很难进行诊断。我们开发了一种非常简单的检测方法，通过CD4+ T细胞表达的两种表面标记物的共同表达来检测对结核病抗原的反应。我们建议与我们的商业合作伙伴Cytognos一起将其开发成一种高度标准化的结核病诊断试剂盒。

Globally, tuberculosis is a leading cause of death with 9.6 million new diagnoses in 2014. The diagnosis of latent TB infection is important, but is difficult to make because current assays are suboptimal. We have developed a very simple assay which detects responses to TB antigens by co-expression of two surface markers expressed by CD4+ T cells. We propose to develop this into a highly standardised kit for the diagnosis of TB with our commercial partner Cytognos.