DEVELOPMENT OF 1H METABOLITE IMAGING FOR CANCER

描述（摘自摘要）：人类癌症的体内1H MRS， 芳香族地区实际上是一个未开发的地区。化合物与 芳香环在生物化学中占有重要的地位 生命系统和癌症的过程。例如， 嘌呤和嘧啶是核苷酸、DNA和RNA的基本部分， 肌肉中的芳香质子还包括对pH敏感的 肌肽咪唑质子。初步高空间分辨率 结果显示，大脑中假定的核苷酸信号 在肿瘤中显著减少。此外，强磁化 转移（MT）的影响，在芳香族质子的大脑已经 观察由于MT的产生依赖于 两个不同质子池之间的磁化交换，这取决于 在组织的生物物理特性上， 正常组织、肿瘤和坏死。因此，在体内1H MRS的人， 芳香区可以补充“传统的”体内1H MRS（即， 信号）的损伤， 肿瘤诊断/预后的独立参数。高 空间分辨率对于区分各种病理 正常组织用于决定性诊断。然而，收购时间长， 短T2、低浓度和脂质/水抑制是主要的 高空间分辨率的体内1H芳香族成像的挑战 癌的新的“回声滤波器”的进一步发展/优化 技术可以同时解决这些技术挑战。的 这项工作的长期目标是评估芳香质子的作用 肿瘤的诊断和预后。具体目标是：（1）进一步 发展回声滤波直接成像技术（即代谢物 没有化学位移演化周期的成像技术）， 芳香族质子; 2）建立正常组织的基线， 用于癌症的体内1H MRS研究的芳香区3）获得 芳香族质子在脑肿瘤和软组织中的初步临床资料 组织肉瘤，以探索这种方法作为诊断的实用性/ 预测工具。这项研究的积极成果将为 在肿瘤的诊断/预后方面进行更集中的临床试验， 芳族质子和MT效应作为新参数。

DESCRIPTION (taken from abstract): In vivo 1H MRS of human cancers in the aromatic region is virtually an unexplored area. Compounds with aromatic rings occupy numerous and important positions in biochemical processes of living systems and cancers. For example, derivatives of purine and pyrimidine are essential parts of nucleotides, DNA and RNA, and the aromatic protons in muscle also include the pH sensitive imidazole proton of carnosine. Preliminary high spatial resolution results have revealed that the putative nucleotide signal in the brain is dramatically reduced in tumors. In addition, strong magnetization transfer (MT) effects in the aromatic protons of the brain have been observed. Since the generation of MT relies on the presence of magnetization exchange between two different proton pools, it depends on the biophysical properties of the tissue which may differ among normal tissues, tumors and necrosis. Thus, in vivo 1H MRS of humans in the aromatic region may compliment `traditional` in vivo 1H MRS (i.e. signals in the up-field region) of lesions by providing new and independent parameters for the diagnosis/prognosis of tumors. High spatial resolution is essential to differentiate various pathologic and normal tissues for decisive diagnosis. However, long acquisition time, short T2, low concentration, and lipid/water suppression are major challenges to high spatial resolution in vivo 1H aromatic imaging of cancers. Further development/optimization of the novel `echo-filter` technique can simultaneously address these technical challenges. The long term goal of the work is to evaluate the role of aromatic protons in the diagnosis/prognosis of tumors. The specific aims are: 1) further develop the echo-filter direct imaging technique (i.e. the metabolite imaging technique without a chemical shift evolution period) for aromatic protons; 2) establish the baseline of normal tissues in the aromatic region for in vivo 1H MRS study of cancers 3) obtain preliminary clinical data of aromatic protons in brain tumors and soft tissue sarcomas to explore the utility of this method as a diagnosis/ prognostic tool. Positive results of this study will pave the way for more focused clinical trials in the diagnosis/prognosis of tumors using aromatic protons and MT effects as new parameters.