NNFF CONSORTIUM:MOLECULAR AND CELL BIOLOGY OF NF1& NF2

国家神经纤维瘤病基金会国际联盟关于NF1和NF2的分子和细胞生物学的下一次会议将于2000年6月4日至7日在科罗拉多州阿斯彭的Jerome酒店举行。从1985年的第一次会议开始，这些会议已经成为许多基础发现的催化剂，这些发现对这些重要的神经系统疾病有重要的见解。这些会议提供了一个定期论坛，汇集了基础研究人员、遗传学家、临床医生和其他熟悉NF1和NF2的人，分享他们最新的研究成果和经验。NNFF联盟在NF1和NF2分子理解的快速进展中发挥了重要作用，包括克隆相关基因、建立诊断测试、探索蛋白质功能、开发动物模型以及建立患者和临床医生网络以促进临床试验。2000年财团会议已被组织为公开会议，并将向一般科学界宣传。每六次平台会议将由该领域的一位专家主持。这些会议将包括2名来自NF研究界的受邀演讲者，其他演讲将从提交的摘要中选择。将鼓励年轻研究者的参与，根据以前的联合会会议，组织者预计演讲者将有相当大的比例是年轻研究者。演讲者将被要求将他们的演讲时间限制在分配时间的一半左右，其余时间用于所有参与者之间的公开讨论。此外，与NF研究直接相关的科学领域或新兴技术领域的四位主讲人的长篇演讲将被纳入一些科学会议。还将举行两次海报会议，这将允许调查人员介绍未被选为口头会议之一的摘要。除了向NF1和NF2的研究人员提供最新的研究进展外，这次会议还将有助于确定我们在知识以及解决这些问题的战略和合作方面的关键差距。对NF1和NF2分子基础的进一步了解将在开发针对这些疾病并发症的改进疗法中发挥重要作用，并对发育神经生物学和癌症研究领域具有广泛的意义。

Funding is requested to support the next meeting of the National Neurofibromatosis Foundation International Consortium for the Molecular and Cell Biology of NF1 and NF2 to be held June 4-7, 2000 at the Hotel Jerome in Aspen, Colorado. Beginning with the first meeting in 1985, these conferences have served as the catalysts for many of the fundamental discoveries that have contributed major insights into these important diseases of the nervous system. These meetings provide a regular forum to bring together basic researchers, geneticists, clinicians, and others familiar with NF1 and NF2 to share their latest research findings and experiences. NNFF Consortia have been instrumental in the rapid advances in the molecular understanding of NF1 and NF2, including the cloning of the responsible genes, establishment of diagnostic tests, exploration of protein function, development of animal models, and creation of a network of patients and clinicians to facilitate clinical trials. The 2000 Consortium meeting has been organized as an open meeting that will be advertised to the general scientific community. Each of six platform sessions will be chaired by an expert in the field. These sessions will include 2 invited speakers from the NF research community with the other presentations to be selected from submitted abstracts. Participation by junior investigators will be encouraged and the organizers anticipate, on basis of previous Consortium meetings, that a substantial percentage of the speakers will be young investigators. Speakers will be instructed to limit their presentations to approximately half of the allotted time, with the remainder dedicated to open discussion among all participants. In addition, longer talks by four keynote speakers who are leaders in scientific fields or emerging technologies that are directly relevant to NF research will be incorporated into some of the scientific sessions. Two poster sessions will also be held which will allow investigators to present abstracts that are not selected for one of the oral sessions. In addition to updating investigators working on NF1 and NF2 on the latest research developments, this meeting will help to identify critical gaps in our knowledge as well as strategies and collaborations to address them. An improved understanding of the molecular basis of NF1 and NF2 will play an essential role in developing improved therapies for the complications of these disorders and has broad implications to the fields of developmental neurobiology and cancer research.