EXPRESSION, STRUCTURE AND FUNCTION OF FILAGGRIN

Profilaggrin是Profilaggrin的加工形式，是 哺乳动物的终末分化的表皮。基于体外实验 实验中，微丝蛋白被认为参与了聚集和 角蛋白中间丝在最后阶段的特异性排列 活体内表皮发育的各个阶段。我们已经探索了 Profilaggrin基因的表达调控及其特征 近端启动子。AP1位点及其同源结合c-fos和 C-jun蛋白使角质形成细胞特异性表达该基因，在 与邻近的Sp1、类Ets和NF-kB元素协调。我们有 发现了一种新的ETS转录蛋白，它似乎在 几种晚期分化基因在鼻咽癌中的表达调控 表皮，包括Profilaggrin。

Filaggrin, the processed form of profilaggrin, is a major product of terminally differentiating mammalian epidermis. Based on in vitro experiments, filaggrin is thought to be involved in the aggregation and specific alignment of keratin intermediate filaments during the final stages of development in the epidermis in vivo. We have explored the regulation of expression of the profilaggrin gene and have characterized the proximal promoter. An AP1 site and its cognate binding c-fos and c-jun proteins confer keratinocyte-specific expression to the gene, in concert with neighboring Sp1, ets-like, and NF-kB elements. We have discovered a novel ets transcription protein that seems to function in the regulation of expression of several late differentiation genes in the epidermis, including profilaggrin.