课题基金 / 基金详情

EPIDERMAL TRANSGLUTAMINASES

EPIDERMAL TRANSGLUTAMINASES
表皮谷氨酰胺转胺酶
批准号：
3810939
负责人：
P STEINERT
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3810939
关键词：
crosslink dipeptides enzyme mechanism enzyme structure human tissue isozymes keratinization laboratory mouse lysine membrane proteins molecular cloning protein glutamine gamma glutamyltransferase protein structure function skin

项目摘要

项目成果

P STEINERT的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Transglutaminases form isodipeptide crosslinks between acceptor amide groups of glutaminyl residues and donor epsilon-NH2 groups of lysines. In the epidermis, and other stratified squamous epithelial tissues, these enzymes are thought to be involved in the crosslinking of putative protein components to form the insoluble cell envelope. Using molecular biology approaches, we have found that there are 3 different transglutaminase activities in normal human and mouse epidermis. These are known as the K, C and E enzymes. Work is in progress to isolate and characterize clones encoding each of these and to determine the likely functions of these different activities in normal and abnormally keratinizing epidermis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
EXPRESSION, STRUCTURE AND FUNCTION OF FILAGGRIN
EXPRESSION, STRUCTURE AND FUNCTION OF LORICRIN, A MAJOR CELL ENVELOPE PROTEIN
EPIDERMAL TRANSGLUTAMINASES
STRUCTURAL FEATURES OF KERATIN AND RELATED INTERMEDIATE FILAMENTS
海外基金