EPIDERMAL TRANSGLUTAMINASES

表皮谷氨酰胺转胺酶

• 批准号: 3810939
• 负责人: P STEINERT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3810939
• 关键词: crosslink; dipeptides; enzyme mechanism; enzyme structure; human tissue; isozymes; keratinization; laboratory mouse; lysine; membrane proteins; molecular cloning; protein glutamine gamma glutamyltransferase; protein structure function; skin

Transglutaminases form isodipeptide crosslinks between acceptor amide groups of glutaminyl residues and donor epsilon-NH2 groups of lysines. In the epidermis, and other stratified squamous epithelial tissues, these enzymes are thought to be involved in the crosslinking of putative protein components to form the insoluble cell envelope. Using molecular biology approaches, we have found that there are 3 different transglutaminase activities in normal human and mouse epidermis. These are known as the K, C and E enzymes. Work is in progress to isolate and characterize clones encoding each of these and to determine the likely functions of these different activities in normal and abnormally keratinizing epidermis.

转谷氨酰胺酶在受体酰胺之间形成异二肽交联