APOLIPOPROTEIN E E4 ALLELE FREQUENCY IN PATIENTS W/ VILIUISK ENCEPHALOMYELITIS

Vilyuisk脑脊髓炎（VE）是一种进行性神经系统疾病 病因不明，导致雅库特人死亡 西伯利亚。 痴呆症通常是在疾病进展的过程中发生的。 大多数患者的疾病。 ApoE-M4等位基因的遗传已被证实是一种遗传性疾病。 被证明是发展为迟发性阿尔茨海默氏症的危险因素 疾病 对ApoE等位基因分布进行遗传分析， 雅库特群体M_2、M_3、M_4 (0.09，0.72，0.19），等位基因与欧洲人群相似。 的 无痴呆的慢性VE患者组ApoE等位基因相同 频率作为对照，但痴呆患者组有一个 与第一组相比，M4等位基因频率高两倍， 对照

Vilyuisk encephalomyelitis (VE) is a progressive neurological disorder of unknown etiology with a fatal outcome that affects the Yakut people of Siberia. Dementia usually develops during the progression of the disease in most of the patients. Inheritance of ApoE-M4 allele has been shown to be a risk factor in developing of late onset Alzheimer's disease. Genetic analysis of the ApoE allele distribution performed in general Yakut population revealed that the frequency of M2, M3, M4 (0.09, 0.72, 0.19), alleles is similar to the European population. The group of chronic VE patients without dementia had the same ApoE allele frequency as controls, but the group of patients with dementias had a two-fold higher M4 allele frequency compared to the first group and controls.