MAGNETIC RESONANCE SPECTROSCOPIC NEOPLASM IMAGING

该项目的总体目标是发展质子磁共振光谱成像（MRSI）技术及其后续应用，以帮助肿瘤患者的诊断和治疗监测。作为一种提供独特生化信息的非侵入性工具，体内核磁共振成像已被证明在癌症研究中具有重要作用。然而，要充分发挥这种强大成像方式的临床潜力，还需要重大的技术改进，特别是在可靠地获取全身肿瘤的体积磁共振成像数据方面。本提案的重点是创新光谱技术的持续技术发展，以实现这些信息的可靠和有效的收集、量化和显示。这些技术将在幽灵、正常志愿者以及患有脑瘤、转移性颈部淋巴结鳞状细胞癌和乳腺癌的患者身上进行测试。随着技术的不断发展，我们将开展一项重点突出、对照良好的临床研究，比较质子核磁共振成像和FDG PET在鉴别放射性坏死和复发性胶质肿瘤方面的能力。

The overall goal of this project is the development of proton magnetic resonance spectroscopic imaging (MRSI) techniques and their subsequent application for aiding in the diagnosis and treatment monitoring of patients with tumors. As a noninvasive tool providing unique biochemical information supplemental to conventional imaging, in vivo MRSI has been shown to have a valuable role in the study of cancer. However, significant technical improvements, particularly for the reliable acquisition of volumetric MRSI data from tumors throughout the body, are needed to fully realize the clinical potential of this powerful imaging modality. This proposal is focused on the continued technical development of innovative spectroscopic techniques for the robust and efficient collection, quantification, and display of this information. The techniques will be tested on phantoms, normal volunteers, as well as patients with brain tumors, metastatic neck nodes of squamous cell carcinomas, and breast cancer. In parallel with the continued technical development, we will conduct a focused, well-controlled clinical study comparing the abilities of proton MRSI and FDG PET for differentiating radiation necrosis from recurrent glial tumors.