Diabolic regulation of macrophage cell death pathways by Legionella

细菌病原体军团菌导致免疫功能低下的人致命的肺炎。感染依赖于一种复杂的分泌机制，它将数百种蛋白质转移到宿主细胞中。这些蛋白质破坏了几种重要的防御途径，包括细胞死亡信号。该项目将突出军团菌如何干扰细胞死亡途径并控制其宿主细胞的存活。这些发现将促进有前途的新抗菌剂的开发。

The bacterial pathogen Legionella causes fatal pneumonia in immuno-compromised humans. Infections depend on a sophisticated secretion machinery that translocates hundreds of proteins into host cells. These proteins subvert several essential defense pathways, including cell death signals. This project will highlight how Legionella interfere with cell death pathways and control the survival of its host cells. These findings will facilitate the development of promising new anti-bacterial agents.