Diagnosing Chromosomal Translocations in Solid Tumours

断裂染色体的错误修复可能会将基因融合在一起，从而导致癌症。目前的临床测试只能检测单个众所周知的基因融合，而不能识别新的融合事件或融合变异。我们开发了一种名为CaptureSeq的诊断技术，能够在患者样本中找到所有融合基因。在这笔赠款中，我们将展示CaptureSeq在诊断癌症患者融合基因方面的用途和优势。

Mis-repair of broken chromosomes can fuse together genes that then cause cancer. Current clinical tests are only capable of detecting single well-known gene fusions and are incapable of identifying new fusion events or fusion variations. We have developed a diagnostic technology, termed CaptureSeq, that is capable of finding all fusion genes in a patient sample. In this grant, we will demonstrate the use and advantages of CaptureSeq for diagnosing fusion genes in cancer patients.