Mechanistic and Functional Drivers of Neochromosome Evolution

新染色体进化的机制和功能驱动因素

• 批准号: nhmrc : 1103685
• 负责人: A/Pr Timothy Mercer
• 金额: $ 52.34万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanistic-functional-drivers-neochromosome-evolution/662686
• 关键词: Mechanistic; Functional; Drivers; Neochromosome; Evolution

Neochromosomes are Frankenstein chromosomes--massive extra chromosomes that are stitched together from 100s of pieces of normal chromosomes. They are found in 3% of cancers, but are common in some types, such as liposarcoma. We have mapped their structure and found they form through punctuated chromosome shattering and gene amplification. We will investigate the precise molecular mechanisms that cause this and the recurrent transcriptional and epigenetic drivers lead to their formation.

新染色体是科学怪人染色体--由数百条正常染色体拼接而成的巨大的额外染色体。它们在3%的癌症中被发现，但在某些类型的癌症中很常见，比如脂肪肉瘤。我们绘制了它们的结构图，发现它们是通过点状染色体破碎和基因扩增形成的。我们将研究导致这一现象的确切分子机制，以及导致它们形成的反复转录和表观遗传驱动因素。