Development and application of a novel technology, CaptureSeq, to focus sequencing to discover genes in ‘empty’ genomic regions associated with disease.

开发和应用新技术 CaptureSeq，重点测序以发现与疾病相关的“空”基因组区域中的基因。

• 批准号: nhmrc : 1062470
• 负责人: A/Pr Timothy Mercer
• 金额: $ 28.12万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-application-novel-associated-disease/454993
• 关键词: Development; application; novel; technology; CaptureSeq

Dr. Mercer will develop a new technology, CaptureSeq that is able to focus RNA sequencing on targeted regions of interest. This focus gives CaptureSeq an unprecedented sensitivity to discover new genes and regulatory elements in regions of the genome that have been associated with disease but are otherwise barren and empty. This project will thereby uncover both new genes candidates for further disease research and develop a technology with unique and widespread research and clinical potential.

默瑟博士将开发一项名为CaptureSeq的新技术，该技术能够将RNA测序集中在感兴趣的目标区域。这种关注赋予了CaptureSeq前所未有的敏感度，可以在基因组中与疾病相关但在其他方面贫瘠和空虚的区域发现新的基因和调控元件。因此，该项目将为进一步的疾病研究发现两个新的候选基因，并开发一种具有独特而广泛的研究和临床潜力的技术。