VIRAL EVASION STRATEGIES--ANALYSIS OF THE HERPES VIRUSES HSV,VZV, AND HHV 6 & 7

人类疱疹病毒与它们的 宿主，直到这些病毒从其潜伏状态被重新激活。连 尽管大多数人对这些病毒具有免疫力，但新病毒的产生 尽管如此，病毒仍有可能发生。一般来说，病毒的这种能力可以做到 因此被归因于允许病毒感染的特定基因功能 免疫系统暂时看不到细胞。我们打算 利用生化、细胞生物学和分子生物学进行研究 方法，三种人类疱疹病毒可能通过的机制： 水痘带状疱疹病毒、人类疱疹病毒-6和人类疱疹病毒-7。在……里面 此外，利用基因打靶技术，我们将在 单纯疱疹病毒1型和2型的动物模型。

The human Herpes viruses lead a life of peaceful co-existence with their host, until these viruses are reactivate from their latent state. Even though most individuals are immune to these viruses, production of new virus can nonetheless occur. Generally, this ability of the virus to do so is attributed to specific gene functions that allow the virus infected cell to become temporarily invisible to the immune system. We intend to investigate, using biochemical, cell-biological and molecular biological methods, the mechanisms by which three human Herpes viruses may do so: Varicella Zoster Virus, Human Herpesvirus-6 and human Herpesvirus-7. In addition, using the technique of gene targeting, we shall construct in animal model for HSV-1 and -2.