CORE--ANIMAL FACILITY

描述(改编自申请者摘要)：动物核心意志 为维持必要的菌株提供基本支持 这个项目是没有商业价值的。它将不支持 用于实验的小鼠的产量，而不是基础水平 为保持独特的小鼠品系所必需的育种。这个 申请者将保留糖尿病小鼠NOD和四只GKO小鼠 在点头的背景上成长起来。此外，调查人员将 维持II类MHC、DM和CIITA GKO小鼠。最后，申请者 将保持LCMB TCR转基因以及两个单链I类 转基因、LCMV gP、RIP和无处不在的表达是转基因的核心。 预计动物核心将是经济的，消除了对 每个调查员都要维持自己的繁殖群体。

Description (adapted from applicant's abstract): The Animal Core will provide the basic support for the maintenance of the strains necessary for this project which are not commercially available. It will not support the production of the mice used in experiments, but rather the basal level of breeding necessary for the maintenance of unique mouse strains. The applicants will maintain the diabetic mouse, NOD, as well as four GKO mice bred onto the NOD background. In addition, the investigators will maintain the class II MHC, DM and CIITA GKO mice. Finally, the applicants will maintain LCMB TCR transgenics as well as two single chain class I transgenic, LCMV gp RIP and ubiquitous expression transgenics at the core. The Animal Core is expected to be economical, eliminating the need for each investigator to maintain their own breeding colonies.