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PROJECT SUMMARY We have developed a novel and powerful mouse model for identifying the mechanisms of Neisseria asymptomatic colonization and persistence. It avoids the issue of host restriction that have greatly impeded the field. It allows us to study two processes that have been intractible to experimention, asymptomatic colonization and persistence. It allows us to identify and dissect mechanisms of Neisseria-host interactions from the standpoint of both host and bacterium. Using this unique model, we will identify immune processes and mouse genes that are critical for host susceptibility to Neisseria asymptomatic colonization/persistence, and bacterial genes that are critical for these processes.
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DOI: 10.1007/978-1-4939-9496-0_23
发表时间: 2019
期刊: Methods in molecular biology
影响因子: --
作者: [Katherine A. Rhodes;Mancheong Ma;Magdalene So]
通讯作者: Katherine A. Rhodes;Mancheong Ma;Magdalene So
DOI: 10.1128/iai.00839-17
发表时间: 2018-05
期刊: Infection and immunity
影响因子: 3.1
作者: [Ma M, Powell DA, Weyand NJ, Rhodes KA, Rendón MA, Frelinger JA, So M]
通讯作者: So M
DOI: 10.1128/mbio.02792-23
发表时间: 2024-01-16
期刊: mBio
影响因子: 6.4
作者: []
通讯作者:
Route of Infection Shapes Immune Responses to Francisella
  • 批准号:
    8375875
  • 项目类别:
  • 资助金额:
    $34.68万
  • 财政年份:
    2012
  • 负责人:
    JEFFREY Allen FRELINGER
  • 依托单位:
Route of Infection Shapes Immune Responses to Francisella
  • 批准号:
    8234185
  • 项目类别:
  • 资助金额:
    $33.64万
  • 财政年份:
    2011
  • 负责人:
    JEFFREY Allen FRELINGER
  • 依托单位:
Immune Evasion by F. tularensis
  • 批准号:
    7727737
  • 项目类别:
  • 资助金额:
    $37.0万
  • 财政年份:
    2009
  • 负责人:
    JEFFREY Allen FRELINGER
  • 依托单位:
Immune Evasion by F. tularensis
  • 批准号:
    8481501
  • 项目类别:
  • 资助金额:
    $34.89万
  • 财政年份:
    2009
  • 负责人:
    JEFFREY Allen FRELINGER
  • 依托单位:
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