Mechanisms of Colonization and Persistence by Neisseria
Mechanisms of Colonization and Persistence by Neisseria
批准号:
9548008
负责人:
JEFFREY Allen FRELINGER
金额:
$37.76万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-01 至 2019-08-31
关键词:
AblationAnestheticsAnimal ModelAntibioticsAntibodiesBacteriaBacterial GenesBone MarrowCell physiologyCellsChimera organismComplementDevelopmentDiseaseGastrointestinal tract structureGenesGeneticGenetic ProcessesGenomeHealthHumanImmuneImmune systemImmunologicsIn VitroInfectionInnate Immune ResponseInvestmentsJointsKnock-outKnowledgeLightMicrobeModelingMusNeisseriaNeisseria gonorrhoeaeNeisseria meningitidisOral cavityPathway interactionsPhenotypePilumPredispositionProceduresProcessResearch PersonnelSpecificitySumSymbiosisSystemTLR4 geneTestingVaccinesVeinsWorkantimicrobialcell typeefficacy testingexperimental studygene interactiongenetic manipulationhost-microbe interactionsin vivointerestmembermicrobiotamouse modelmutantnovelpathogenpermissivenessresidencetool
中文摘要
点击翻译按钮获取中文摘要
英文摘要
PROJECT SUMMARY
We have developed a novel and powerful mouse model for identifying the
mechanisms of Neisseria asymptomatic colonization and persistence. It avoids
the issue of host restriction that have greatly impeded the field. It allows us to
study two processes that have been intractible to experimention, asymptomatic
colonization and persistence. It allows us to identify and dissect mechanisms of
Neisseria-host interactions from the standpoint of both host and bacterium.
Using this unique model, we will identify immune processes and mouse genes
that are critical for host susceptibility to Neisseria asymptomatic
colonization/persistence, and bacterial genes that are critical for these
processes.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1007/978-1-4939-9496-0_23
发表时间:
2019
期刊:
Methods in molecular biology
影响因子:
--
作者:
[Katherine A. Rhodes;Mancheong Ma;Magdalene So]
通讯作者:
Katherine A. Rhodes;Mancheong Ma;Magdalene So
DOI:
10.1128/iai.00839-17
发表时间:
2018-05
期刊:
Infection and immunity
影响因子:
3.1
作者:
[Ma M, Powell DA, Weyand NJ, Rhodes KA, Rendón MA, Frelinger JA, So M]
通讯作者:
So M
DOI:
10.1128/mbio.02792-23
发表时间:
2024-01-16
期刊:
mBio
影响因子:
6.4
作者:
[]
通讯作者:
Route of Infection Shapes Immune Responses to Francisella
-
批准号:8375875
-
项目类别:
-
资助金额:$34.68万
-
财政年份:2012
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Route of Infection Shapes Immune Responses to Francisella
-
批准号:8234185
-
项目类别:
-
资助金额:$33.64万
-
财政年份:2011
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Immune Evasion by F. tularensis
-
批准号:7727737
-
项目类别:
-
资助金额:$37.0万
-
财政年份:2009
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Immune Evasion by F. tularensis
-
批准号:8481501
-
项目类别:
-
资助金额:$34.89万
-
财政年份:2009
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Immune Evasion by F. tularensis
-
批准号:8286237
-
项目类别:
-
资助金额:$37.12万
-
财政年份:2009
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Immune Evasion by F. tularensis
-
批准号:8123149
-
项目类别:
-
资助金额:$37.12万
-
财政年份:2009
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Route of Infection Shapes Immune Responses to Francisella
-
批准号:7671889
-
项目类别:
-
资助金额:$13.26万
-
财政年份:2009
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Immune Evasion by F. tularensis
-
批准号:7896798
-
项目类别:
-
资助金额:$37.5万
-
财政年份:2009
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Genetics of Host Resistance to Franciscella tularensis in Mice
-
批准号:7259227
-
项目类别:
-
资助金额:$21.9万
-
财政年份:2007
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Genetics of Host Resistance to Franciscella tularensis in Mice
-
批准号:7479604
-
项目类别:
-
资助金额:$17.9万
-
财政年份:2007
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Targeting CD8+ T Cells to Prevent b Cell Destruction
-
批准号:7010330
-
项目类别:
-
资助金额:$35.05万
-
财政年份:2003
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Targeting CD8+ T Cells to Prevent b Cell Destruction
-
批准号:6796731
-
项目类别:
-
资助金额:$25.55万
-
财政年份:2003
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Targeting CD8+ T Cells to Prevent b Cell Destruction
-
批准号:6616389
-
项目类别:
-
资助金额:$8.52万
-
财政年份:2003
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Targeting CD8+ T Cells to Prevent b Cell Destruction
-
批准号:6838195
-
项目类别:
-
资助金额:$25.55万
-
财政年份:2003
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Targeting CD8+ T Cells to Prevent b Cell Destruction
-
批准号:7074938
-
项目类别:
-
资助金额:$6.43万
-
财政年份:2003
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Targeting CD8+ T Cell to Prevent B Cell Destruction
-
批准号:7895514
-
项目类别:
-
资助金额:$37.88万
-
财政年份:2003
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Targeting CD8+ T Cells to Prevent b Cell Destruction
-
批准号:7160564
-
项目类别:
-
资助金额:$35.12万
-
财政年份:2003
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
Targeting CD8+ T Cell to Prevent B Cell Destruction
-
批准号:7386064
-
项目类别:
-
资助金额:$36.99万
-
财政年份:2003
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
CORE--SIMIAN AND RODENT IMMUNOLOGY FACILITY
-
批准号:6352654
-
项目类别:
-
资助金额:$40.36万
-
财政年份:2000
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
CORE--ANIMAL FACILITY
-
批准号:6338620
-
项目类别:
-
资助金额:$18.99万
-
财政年份:2000
-
负责人:JEFFREY Allen FRELINGER
-
依托单位:
海外基金