Dilinoleoyl phosphatidic acid as a novel mediator of insulin resistance in muscle
Dilinoleoyl phosphatidic acid as a novel mediator of insulin resistance in muscle
批准号:
nhmrc : 481317
负责人:
A/Pr Carsten Schmitz-Peiffer
金额:
$33.61万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
我们已经在肌肉中发现了一种新的脂肪分子,它可能在肥胖期间引起胰岛素抵抗中发挥重要作用,胰岛素抵抗是2型糖尿病发展的一个主要因素。我们现在将研究这种分子,二烯油酰磷脂酸的消耗是否可以改善肌肉和肥胖小鼠的胰岛素作用,并研究它可能起作用的机制。这项工作可能为糖尿病的治疗提供新的策略。
英文摘要
We have identified a novel fat molecule in muscle which may play an important role in causing insulin resistance during obesity, a major factor in the development of Type 2 diabetes. We will now examine whether depletion of this molecule, dilinoleoyl-phosphatidic acid, can improve insulin action in muscles and in obese mice, and investigate the mechanisms by which it may act. This work may indicate new strategies for the treatment of diabetes.
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会议论文
Action of PKC epsilon in Adipose Tissue Regulates Hepatic Glucose Production
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批准号:nhmrc : GNT1081869
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项目类别:Project Grants
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资助金额:$87.25万
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财政年份:2015
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负责人:A/Pr Carsten Schmitz-Peiffer
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依托单位:
Action of PKC epsilon in Adipose Tissue Regulates Hepatic Glucose Production
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批准号:nhmrc : 1081869
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项目类别:Project Grants
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资助金额:$60.47万
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财政年份:2015
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负责人:A/Pr Carsten Schmitz-Peiffer
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依托单位:
Targeting ceramide metabolism to improve lipid-induced insulin resistance
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批准号:nhmrc : 1005819
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项目类别:NHMRC Project Grants
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资助金额:$40.3万
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财政年份:2011
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负责人:A/Pr Carsten Schmitz-Peiffer
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依托单位:
The regulation of insulin action in liver and skeletal muscle by Protein kinase C epsilon
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批准号:nhmrc : 535917
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项目类别:NHMRC Project Grants
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资助金额:$43.18万
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财政年份:2009
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负责人:A/Pr Carsten Schmitz-Peiffer
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依托单位:
Therapeutic Strategies and Screening Methods for PKC epsilon antagonists in the treatment of Type 2 diabetes
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批准号:nhmrc : 427629
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项目类别:NHMRC Development Grants
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资助金额:$10.49万
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财政年份:2007
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负责人:A/Pr Carsten Schmitz-Peiffer
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依托单位:
Investigation of the Roles of Protein Kinase C epsilon in Insulin Secretion and Insulin Clearance
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批准号:nhmrc : 376022
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项目类别:NHMRC Project Grants
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资助金额:$41.82万
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财政年份:2006
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依托单位:
The Role of Protein Kinase C epsilon in the Generation of Lipid-Induced Insulin Resistance in Skeletal Muscle
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批准号:nhmrc : 230822
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项目类别:NHMRC Project Grants
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资助金额:$31.66万
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财政年份:2003
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负责人:A/Pr Carsten Schmitz-Peiffer
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依托单位:
海外基金