INTERVENTIONS TO IMPROVE MEMORY IN PATIENTS WITH MS

描述(改编自研究人员摘要)：认知功能障碍 多发性硬化症(MS)致残的主要原因之一， 巨大的社会经济和人际关系损失。不幸的是，之前 治疗多发性硬化症认知功能障碍的尝试有限 成功。调查人员打算克服以前的限制 研究人员：1)测试特定目标干预措施的有效性 认知功能；以及2)使用一种新的结果测量方法，该方法可能 对发生的认知功能障碍更敏感和更生态有效 在MS中，拟议的实验将确定多奈哌齐的疗效。 治疗和葡萄糖治疗对改善记忆功能的作用 与调查人员一起的个人也将衡量次要结果 评估认知功能障碍的其他领域(即，非语言记忆， 概念性思维、处理速度)，这可能会通过干预而提高。

DESCRIPTION (adapted from investigator's abstract): Cognitive dysfunction is one of the leading causes of disability in multiple scelerosis (MS), exacting a tremendous socioeconomic and interpersonal toll. Unfortunately, previous attempts to rehabilitate cognitive dysfunction in MS have had only limited success. The investigators intend to overcome the limitations of previous studies by: 1) testing the efficacy of interventions that specifically target cognitive functioning; and 2) utilizing a novel outcome measurement that may be more sensitive and ecologically valid for the cognitive dysfunction that occurs in MS. The proposed experiments will determine the efficacy of donepezil therapy and glucose administration for enhancing memory functioning in individuals with MS. The investigators will also measure secondary outcomes assessing other areas of cognitive dysfunction (i.e., nonverbal memory, conceptual thinking, processing speed) which may improve with intervention.