QUALITY OF LIFE AND TREATMENT FOR BRAIN TRAUMA

描述（改编自申请人摘要）： 生命评估正迅速成为评估生命质量的一个不可或缺的工具 医学上的成果。通过解决患者健康质量问题， 这些评估大大加强了治疗研究 有效性，它们用于研究成本和结果的关系 (i.e.,成本效益分析），并提供了一个通用的标准， 预防、康复和治疗比较健康测量 治疗。这个指导研究科学家发展奖是由 候选人准备他帮助领导康复，因为它有助于 这种对医学结果的综合研究方法。建议5- 年度课程工作计划，研究研讨会，并监督健康研究 服务，流行病学和健康决策分析是提供 候选人具有作为独立研究员所需的技能 在康复和脑创伤成本和结果研究领域。一个 与健康有关的生活质量的实验研究，将在 最近NIH资助了一项名为“硫酸镁”的随机临床试验 脑外伤后，提出。这项关于镁的随机临床试验 硫酸盐作为脑外伤后的神经保护剂将招募400名受试者， 正在收集死亡率癫痫发作频率和神经行为数据的 拟议的研究将对试验参与者进行双盲访谈， 损伤后6个月，以获得健康相关的生活质量数据。采访 将使用EuroQol确定受试者的当前健康状况 分类系统（EQ-SD）。受试者将评估他们目前的健康状况 使用三种经过验证的技术：标准赌博，时间权衡， 视觉焦虑量表。主要假设是硫酸镁， 中度或重度头部损伤后8小时内，改善受试者评估 他们受伤后6个月的健康状况。该研究还将评估 通过测试每种评估方法，了解与每种评估方法相关的认知负担 受试者对当前健康状况的价值观的一致性。一致 受试者将判断其他假设的健康状态，以构建一个 用于评估对象的替代加权方案 这是一个巨大的认知负担。最后，候选人计划使用收集的数据 从关于损伤严重程度和认知障碍的临床试验， 认知功能障碍与健康相关质量的关系 生命的判断，并制定方法来预测伤害的严重程度时， 干扰这些判断。

DESCRIPTION (Adapted from Applicant's Abstract): Health-related quality of life assessment is rapidly becoming an indispensable tool for evaluating outcome in medicine. By addressing the quality of patient health after treatment, these assessments greatly enhance the study of treatment effectiveness, they are used in the study of cost and outcome relationships (i.e., cost-effectiveness analysis), and they offer a universal standard in health measurement for comparison of preventive, rehabilitative, and curative treatments. This Mentored Research Scientist Development Award is proposed by the candidate to prepare him to help lead rehabilitation as it contributes to this integrative approach to the study of outcome in medicine. The proposed 5- year plan of course work, research seminars, and supervised research in health services, epidemiology, and health decision analysis is to provide the candidate with the necessary skills to function as an independent researcher in the area of rehabilitation and brain trauma cost and outcomes research. An experimental study of health-related quality of life, to be conducted within a recently NIH-funded randomized clinical trial, entitled "Magnesium Sulfate After Brain Trauma", is proposed. This randomized clinical trial of magnesium sulfate as a neuroprotectant after brain trauma will enlist 400 subjects and is collecting mortality, seizure frequency, and neurobehavioral data. The proposed study will conduct double-blind interviews with trial participants at 6 months post injury to obtain health-related quality of life data. Interviews will determine subjects' current health status using the EuroQol classification system (EQ-SD). Subjects will then value their current health using three well validated techniques: The Standard Gamble, Time Tradeoff, and Visual Analogue Scale. The primary hypothesis is that magnesium sulfate, given within 8 hours of moderate or severe head injury, improves subject valuation of their current health at 6 months post-injury. The study will also evaluate the cognitive burden associated with each method of valuation by testing each subject's consistency in placing values on their current health. Consistent subjects will judge additional hypothetical health states to construct a surrogate weighting scheme for use with subjects for which valuation is of too great a cognitive burden. Finally, the candidate plans to use data collected from the clinical trial on injury severity and cognitive impairment to both study the relationship between cognitive impairment and health-related quality of life judgments, and to develop ways to predict when injury severity will interfere with these judgments.