CLUSTERING AND HYPER-LINKING OF LONG-TERM EEGS

拟议的工作是对第一阶段开发的MagicMarker软件的改进，该软件为显示和分析长期脑电记录提供了一种新的方法。相似活动的纪元通过两遍层次聚类被分成段和状态。这导致了明显不同的背景、阵发性活动和患者状态转换。底层的EEG总是可以通过超级链接获得，这样就可以将伪像与“真实的EEG”区分开来。第二阶段的工作为第一阶段的软件增加了分类能力(智能)。提出了一个专家级癫痫检测器、一个ICU异常检测器和一个用户定义的活动检测器。这项工作包括开发一个大型资料库，其中包括仔细分析和注释的长期脑电研究。新生儿、年龄较大的儿童和成年人将被包括在内，以确保针对所有年龄段的强大算法。拟议的软件通过对感兴趣的事件进行智能通知(视觉、声音和拨号寻呼机)，大大减少了工作人员对长期监测的需求。这项技术除了能够在“实验室之外”监测患者外，还能提供更频繁的患者检查和改善的临床结果。拟议的商业应用拟议的软件将是任何数字脑电的宝贵补充，因为它为神经学家和脑电技术人员提供了巨大的节省时间。该软件将与目前的PerSyst产品(Insight、SpikeDetector和Prism)一起销售，这些产品支持并由几乎所有主要的DEEG制造商销售。

The proposed work offers enhancements to the MagicMarker software developed in Phase I. This software offers a new methodology for the display and analysis of long-term EEG records. Epochs of similar activity are grouped into segments and then states via two-pass hierarchial clustering. This results in clearly differentiated background, paroxysmal activity and patient state transitions. The underlying EEG is always available via hyper- links so that artifacts can be distinguished from "real EEG." The Phase II work adds classification abilities (intelligence) to the Phase I software. Proposed are an expert-level seizure detector, an ICU abnormality detector and a user-defined activity detector. The effort includes the development of a large library of carefully analyzed and annotated prolonged EEG studies. Newborns, older children and adults will be included ensuring robust algorithms for all age groups. The proposed software greatly reduces staff requirements for long-term monitoring through intelligent notification (visual, audible and dial-up pager) of interesting events. This, in addition to the ability to monitor patients "away from the lab," provides more frequent patient checks and improved clinical outcomes. PROPOSED COMMERCIAL APPLICATION The proposed software would be a valuable addition to any digital EEG because of the great timesavings it provides for both neurologists and EEG technicians. The software will be marketed along with current Persyst products (Insight, SpikeDetector and Prism), which support and are sold by virtually every major DEEG manufacturer.