COGENT FOR MOOD AND ANXIETY DISORDER RESEARCH

描述（改编自申请人的摘要）：这是一个请求， 纽约州加强神经科学转移的核心资助（CoGENT） 精神病院。十个合格的基础赠款的心情和焦虑 研究领域已被选定。这些赠款代表了一种多样性 专业知识，技术和科学方法，从基础到 治疗研究。包括涉及神经影像学的研究， 电生理学，遗传标记，脑脊液神经递质代谢物研究 和蛋白质，治疗难治性患者，治疗老年人， 考虑共病疾病和生态有效的研究设计。 拟议的CoGENT的主要目标是将这些技术和各种 专业领域，使多个研究可以受益。我们尤其 致力于神经成像，电生理学，应用现代神经科学 先进的大脑蛋白质化学和遗传标记等技术 分析治疗研究。通过这样做，我们希望能够加快 努力把我们对精神病理学和治疗的理解放在一个 神经科学平台拟议的CoGENT建立在优势之上 在近二十年的资金积累，通过心理健康 临床研究中心（MHCRC）计划。具体来说，三个核心， 我们的MHCRC已经被证明是成功的和宝贵的， 包括在这个提案中。实验室和技术支持（LTS） 核心（原生物研究单位），中央正常对照 招募（CNCR）核心，以及生物统计学，数据管理和网络 （BDMN）核心。这三个核心将支持十个基本赠款，提供共同的 促进技术和知识转让的资源 科学家，并鼓励开发新的研究， 接近。

DESCRIPTION (Adapted from the Applicant's Abstract): This is a request for a Core Grant to Enhance Neuroscience Transfer (CoGENT) from the New York State Psychiatric Institute. Ten qualifying Base Grants in the mood and anxiety disorders research area have been selected. These grants represent a diversity of expertise, technologies, and scientific approaches, ranging from basic to treatment studies. Included are studies involving neuroimaging, electrophysiology, genetic markers, study of CSF neurotransmitter metabolites and proteins, treatment of refractory patients, treatment of the elderly, and consideration of comorbid disorders and ecologically-valid research designs. The main goal of the proposed CoGENT is to link these technologies and diverse areas of expertise so that multiple studies can benefit. In particular, we are dedicated to neuroimaging, electrophysiology, applying modern neuroscience technologies such as advanced brain protein chemistry, and genetic marker analysis to treatment research. In so doing, we hope to be able to speed the effort toward placing our understanding of psychopathology and treatment on a firm neuroscience platform. The proposed CoGENT builds upon strengths accumulated during nearly two decades of funding through the Mental Health Clinical Research Center (MHCRC) program. Specifically, three cores that have proven both successful and invaluable from our MHCRC have been revised and are included in this proposal. They are the Laboratory and Technical Support (LTS) Core (formerly the Biological Studies Unit), the Centralized Normal Control Recruitment (CNCR) Core, and the Biostatistics, Data Management, and Networking (BDMN) Core. These three cores will support the ten Base Grants, provide common resources that will facilitate technology and knowledge transfer among scientists, and encourage the development of novel research studies and approaches.