CORE--NEUROPATHOLOGY

加州大学洛杉矶分校阿尔茨海默病研究的神经病理学(NP)核心 中心(以下简称ADRC)将进行完整的或“仅限大脑”的尸检 关于参加尸检计划的患者，以及患有 神经退行性疾病(和适当的控制)，并将严重 作为个人的数据和组织/体液资源 阿尔茨海默病/阿尔茨海默病的创新性研究 类型(AD/SDAT)、非AD痴呆症和其他感兴趣的科学家 神经退行性疾病。来自适当尸检的脑组织 将在尸检时进行分类和存储，以便优化 他们随后对结构和分子/药理学研究的使用。 组织采集方法将是在第一次开发期间开发的方法 加州大学洛杉矶分校阿尔茨海默病中心(ADC)八年的资助， 即材料将被冷冻储存，多聚甲醛固定(与 随后包埋在LR白色塑料中)或石蜡块中。组织 对NP核心的研究将包括对固定大脑的系统性阻断 组织、常规和特化银质菌株 与AD相关的显微镜损害(老年斑和神经原纤维 Tangles)，以及商用的免疫组织化学染色 在NP中形成的可用抗体和抗体/试剂/探针 核心或与合作的调查人员。因此，提供了组织/液体 对调查人员进行了仔细和系统的评估 用于AD和相关疾病过程。有关已验尸病人的资料 也将提交到ADRC数据库并在其中维护， 确保其可供进行以下两种临床试验的研究人员使用 或者基础研究。核电核心的其他一般职能包括 (A)与临床核心和影像分核心的互动，以提供 用于ApoE基因分型和其他工作的组织，(C) 持续AD相关的形态/免疫组化支持(和 基于动物模型)研究和项目负责人通过直接协作 或提供关键试剂；(D)与社区病理学家联络 他们被要求对痴呆症的尸检脑组织进行评估 病人，(D)与非专业团体讨论尸检的重要性 (E)与教育中心合作，以 指导、优化和评估每月痴呆症的教学价值- 相关临床病理会议。

The Neuropathology (NP) Core of the UCLA-Alzheimer's Disease Research Center (hereafter ADRC) will perform complete or "brain only" autopsies on patients enlisted in the Autopsy Program, as well as patients with over neurodegenerative diseases (and appropriate controls) and will sere as a data and tissue/fluid resource for individuals performing innovative research on Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), non-AD dementias, and other scientists interested in neurodegenerative conditions. Brain tissues from appropriate autopsies will be triaged and stored at the time of necropsy in order to optimize their subsequent use of structural and molecular/pharmacologic research. The tissue harvesting method will be one developed during the first eight years of funding of the UCLA Alzheimer's Disease Center (ADC), i.e. materials will be stored frozen, paraformaldehyde fixed (with subsequent embedding in LR White plastic), or in paraffin blocks. Tissue studies in the NP Core will include systematic blocking of fixed brain tissue, routine and specialized silver strains that demonstrate microscopic AD-related lesions (senile plaques and neurofibrillary tangles), and immunohistochemical staining using both commercially available antibodies and antibodies/reagents/probes developed in the NP Core or with collaborating investigators. Thus tissues/fluids provided to investigators will have been carefully and systematically assessed for AD and related disease processes. Information on autopsied patients also will be submitted to, and maintained in, the ADRC Database, ensuring its availability to investigators carrying out either clinical or basic studies. Other general functions of the NP Core will include (a) Interactions with the Clinical Core and Imaging Sub-core to provide tissues for ApoE genotyping and other work, (c) Morphologic/immunohistochemical support of ongoing AD-related (and animal model-based) studies and Project Leaders by direct collaboration or provision of key reagents, (d) Liaison with community pathologists who are called upon to asses autopsy brain tissue from demented patients, (d) Discussion with lay groups of the importance of autopsies on demented patients, and (e) Collaborating with the Education Core to conduct, optimize and assess the didactic value of a monthly dementia- related clinicopathologic conference.