MARK I, RESEARCH IRRADIATOR WITH CESIUM 137 SOURCE

该申请要求资金购买铯137辐照源，用于在加州大学弗朗西斯科分校（UCSF）帕纳萨斯高地校区的屏障动物护理设施（ACF）内运行。 帕纳萨斯高地是加州大学旧金山分校教学、研究和病人护理的主要场所。将该仪器放置在ACF内将允许11名在免疫学，传染病，造血和癌症生物学领域工作的合作研究人员，他们的实验室位于Parnassus校园内，以进行NIH资助的研究项目不可或缺的实验，并将造血细胞转移到辐照小鼠中。为ACF采购铯辐照器将确保这些研究有效、安全地进行，并遵循在屏障动物护理机构受控环境中进行工作的既定程序。 申请人小组具有良好的研究生产力记录和相互合作的良好历史。 目前，Parnassus校园内没有辐射源可供照射小动物。 现有的程序是昂贵的，繁琐的，效率低下的，因为它们涉及住房小鼠在不同的网站从研究人员的实验室或转移动物到另一个网站在旧金山弗朗西斯科的辐射，然后将它们运回帕纳萨斯校园。 该仪器将被安置在ACF内，将为该设施的基础设施增加一个重要的新组件，并将大大加强UCSF研究人员以及申请人的研究工作。 申请书证明了对该提案的强有力的机构支持。

This application requests funds to purchase a cesium 137 irradiation source to operate within the barrier Animal Care Facility (ACF) at the Parnassus Heights campus of the University of California, San Francisco (UCSF). Parnassus Heights is the major site of teaching, research, and patient care at UCSF. Locating this instrument within the ACF will allow 11 co-investigators working in the areas of immunology, infectious disease, hematopoiesis, and cancer biology whose laboratories are located on the Parnassus campus to perform experiments which are integral to NIH-funded research projects and which involve transferring hematopoietic cells into irradiated mice. Acquisition of a cesium irradiator for the ACF will ensure that these studies are carried out efficiently, safely, and in a manner that follows well-established procedures for conducting working within the controlled environment of a barrier animal care facility. The applicant group has a excellent record of research productivity and a strong history of collaborating with each other. At present, there is no radiation source available for irradiating small animals at the Parnassus campus. Existing procedures are expensive, cumbersome, and inefficient as they involve housing mice at a different site from the investigator s laboratory or transferring animals to another site within San Francisco for radiation, and then transporting them back to the Parnassus campus. The instrument will be housed within the ACF, will add an important new component to the infrastructure of that facility, and will greatly enhance research efforts of UCSF investigators in addition to the applicant group. The application documents strong institutional support for the proposal.