CORE-- CLINICAL

加州大学戴维斯分校阿尔茨海默病中心（UCD ADC） 旨在促进对北方加州老年痴呆症的研究 通过为调查人员创建一个集中的来源， 以及充分表征的痴呆患者和正常对照， 维护这些临床和神经病理学结果的数据库， 科目 UCD ADC有一个大而多样的集水区， 包括主要城市和郊区的旧金山弗朗西斯科，旧金山 何塞，奥克兰和萨克拉门托，农业中心的大部分 山谷，以及东部和北部的农村地区。 患者从 加州大学戴维斯分校诊所和设施的广泛网络，以4 ADC 2个主要诊所（伯克利和萨克拉门托）和2个 卫星诊所（奥克兰和约洛县）。 临床核心提供 将联合收割机这些临床痴呆评估结合起来的资源和人员 将这些设施纳入一个具有共同研究使命的综合计划。 核心的主要功能是：1）创造一个种族多样性 受试者库由经过仔细诊断和充分表征的 痴呆患者和正常对照组，2）收集全面， 标准化的临床数据，3）创建和管理一个 诊断、临床和神经病理学结果的中央数据库， 4)提供纵向跟踪，5）支持研究， 识别和招募特定研究的患者和对照，以及 6)开办卫星诊所，便利少数民族和 老年痴呆症的研究。 核心 招募并评估人口统计学匹配的对照组受试者， 与患者相同的协议和方法， 注意跨站点和评分者间的可靠性问题， 开发创新的临床数据定量方法。 最后，核心有助于对有研究兴趣的患者进行尸检。 在这次更新中，临床核心提出了对 它在第一个供资周期采用的方法。 芯会 每年评估约300例新患者和100例新对照 获得标准化的病史，神经学检查，神经成像， 实验室、神经心理学、行为学和精神病学数据。 它将保持其纵向队列约300名患者， 是高质量的研究对象，并创建一个可比较的纵向 200名同意尸检的对照受试者的随访队列。 核心组织的两个卫星诊所已经发展出有效的外展方法， 这导致了大量的少数民族患者; 核心将建立在这一临床基础上， 多样化和平衡的研究和尸检样本。 所有受试者的数据 将被输入到一个广泛的数据库，核心将帮助招募 这些课题在个别研究项目中，跟踪研究 参与，并帮助进行尸检。

The Clinical Core of the UC Davis Alzheimer's Disease Center (UCD ADC) seeks to facilitate research on Alzheimer's disease in Northern California by creating for investigators a centralized source of carefully evaluated and well characterized dementia patients and normal controls and maintaining a database of clinical and neuropathological findings on these subjects. The UCD ADC has a large and diverse catchment area, encompassing the major cities and suburban areas of San Francisco, San Jose, Oakland, and Sacramento, large portions of the agricultural Central Valley, and rural areas to the east and north. Patients are referred from an extensive network of UC Davis clinics and facilities to 4 ADC performance sites; 2 main clinics (Berkeley and Sacramento) and 2 satellite clinics (Oakland and Yolo County). The Clinical Core provides the resources and personnel to combine these clinical dementia evaluation facilities into an integrated program with a shared research mission. The major functions of the Core are: 1) to create an ethnically diverse subject pool consisting of carefully diagnosed and well characterized dementia patients and normal controls, 2) to collect comprehensive and standardized clinical data on these subjects, 3) to create and manage a central database of diagnostic, clinical, and neuropathological findings, 4) to provide longitudinal follow-up, 5) to support research by identifying and recruiting patients and controls for specific studies, and 6) to operate satellite clinics to facilitate access of minority and under-served populations to Alzheimer's disease research. The Core recruits and evaluates demographically matched control subjects using the same protocols and methods as for patients and devotes considerable attention to issues of cross-site and inter-rater reliability, and to the development of innovative methods for quantitating clinical data. Finally, the Core facilitates autopsy for patients of research interest. In this renewal the Clinical Core proposes evolutionary modifications of the methods it employed in its first funding cycle. The Core will evaluate approximately 300 new patients and 100 new controls per year obtaining standardized histories, neurological exams, neuroimaging, laboratory, neuropsychological, behavioral and psychiatric data on all. It will maintain its longitudinal cohort of approximately 300 patients who are high quality research subjects and create a comparable longitudinal follow-up cohort of 200 control subjects who have consented to autopsy. The Core's two satellite clinics have evolved effective outreach methods which have resulted in substantial numbers of ethnic minority patients; the Core will build upon this clinical base to achieve an ethnically diverse and balanced research and autopsy sample. Data from all subjects will be entered to an extensive database and the Core will help enlist these subjects in individual research projects, track research participation, and help obtain autopsy.