A multi-cohort investigation of the effects of BDNF Val66Met on tau, neurodegeneration and cognition in preclinical Alzheimer’s disease

目前还没有针对阿尔茨海默病的疾病修饰疗法。我们将阐明一种遗传多态性的作用，这种多态性先前已被证明对与阿尔茨海默病相关的记忆力下降和脑容量损失具有神经保护作用。通过研究这种基因在具有不同程度阿尔茨海默病风险的多个个体队列中的作用，这项研究很有可能发现治疗这种疾病的新的疾病修饰策略。

There are currently no disease modifying therapies for Alzheimer’s disease. We will elucidate the role of a genetic polymorphism that has previously been shown to exert neuroprotective effects on memory decline and brain volume loss associated with Alzheimer’s disease. By studying the role of this gene in multiple cohorts of individuals with varying degrees of Alzheimer’s disease risk, this study has high potential to uncover novel disease-modifying strategies for the treatment of the disease.