Biological, genetic and lifestyle moderators of Alzheimer's pathogenesis, cognitive decline and clinical disease progression

阿尔茨海默病发病机制、认知能力下降和临床疾病进展的生物、遗传和生活方式调节因素

• 批准号: nhmrc : GNT1162645
• 负责人: Dr Yen Ying Lim
• 金额: $ 43.7万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biological-genetic-lifestyle-disease-progression/1349364
• 关键词: Biological; genetic; lifestyle; moderators; Alzheimer

Alzheimer’s disease (AD) is the most common form of dementia, and the number of people living with it will triple by 2050. There is currently no cure for AD, and the only means of slow the growing epidemic is to delay onset. We propose to understand the complex interplay between genetic, cognitive, neuroimaging and biological markers of AD in order to better understand the disease process, and in turn identify high-risk individuals for clinical trials and uncover disease-modifying strategies.

阿尔茨海默病（AD）是最常见的痴呆症，到2050年，患有这种疾病的人数将增加两倍。目前还没有治愈AD的方法，减缓日益增长的流行病的唯一手段是延迟发病。我们建议了解AD的遗传、认知、神经影像学和生物学标志物之间的复杂相互作用，以便更好地了解疾病过程，进而识别临床试验的高风险个体并发现疾病修饰策略。