MONKEY MODEL OF LATE ONSET MYOPIA

生命早期，在与快速婴儿期相对应的年龄 在人类眼睛生长的过程中，视觉反馈可以调节屈光 在猴子和许多其他物种中的发育。要确定是否 视觉依赖机制仍然可以影响屈光发育 在灵长类动物眼球生长的缓慢幼年阶段，时间 近视在人类儿童中的典型发展时期，我们检查了 花样视觉剥夺对青春期猴子的影响。 视力剥夺的发病年龄在3.7岁至5岁之间， 这与大约15到20岁之间的发病年龄相对应。这个 用睫状肌麻痹评估模式剥夺的眼部效应 验光和A超检查。在模式开始的时候 剥夺，所有4只猴子都是屈光参差(平均屈光不正 左眼和右眼)，2只眼的眼轴尺寸为 搭配得很好。在71到80周的模式剥夺之后，所有的 视觉剥夺的人的眼睛看起来比 他们的未经治疗的同胞眼睛，他们表现出相对增加的 玻璃体深度和轴向长度。因此，我们现在有 证明了视觉依赖机制可以影响眼睛 青春期猴子的生长和屈光发育。这些结果 提高视觉体验可能涉及的可能性 儿童学龄期近视的发生机制。资助伊利诺伊大学 休斯顿$10,000 9/01/96-4/30/99史密斯，EL III，布拉德利， D.V.，Fernandes，A.和Boothe，R.G.形觉剥夺近视 青春期猴子。奥普托姆。维。SCI。(记者发稿)。P51RR00165-38 1998年1月1日-1998年12月31日耶克斯地区灵长类研究中心

Early in life, at ages corresponding to the rapid infantile phase of ocular growth in humans, visual feedback can modulate refractive development in monkeys and many other species. To determine if vision-dependent mechanisms can still influence refractive development in primates during the slow juvenile phase of ocular growth, the time period when myopia typically develops in human children, we examined the effects of patterned visual deprivation on adolescent monkeys. The onset of visual deprivation was between 3.7 and 5 years of age, which corresponds to onset ages between about 15 and 20 years. The ocular effects of pattern deprivation were assessed by cycloplegic retinoscopy and A-scan ultrasonography. At the onset of pattern deprivation, all 4 monkeys were isometropic (equal refractive error in the left and right eyes) and the axial dimensions in the 2 eyes were well matched. Following 71 to 80 weeks of pattern deprivation, all of the visually deprived ey es had bec ome relatively more myopic than their fellow non-treated eyes and they exhibited relative increases in vitreous chamber depth and axial length. Therefore, we have now demonstrated that vision-dependent mechanisms can influence ocular growth and refractive development in "teenage" monkeys. These results raise the possibility that visual experience may be involved in the genesis of school-age myopia in children. FUNDING University of Houston $10,000 9/01/96 - 4/30/99 PUBLICATIONS Smith, EL III, Bradley, D.V., Fernandes, A. and Boothe, R.G. Form deprivation myopia in adolescent monkeys. Optom. Vis. Sci. (In press). P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center