EARLY FUNCTIONAL & STRUCTURAL REPAIR IN MACAQUE STRABISMUS

这项研究的长期目标是揭示神经 解释婴儿的每一种行为缺陷的机制 斜视（眼位不正），以及 它们发生了。 该项目的具体目标是确定眼睛是否 在关键时期早期的重新调整可以修复这些行为， 以及视觉皮层的结构缺陷 新生的猕猴 戴着布拉德利博士为猴子设计的护目镜， 安装棱镜镜片，以诱发光学斜视。 斜视将在出生后三个年龄中的一个进行修复（3 周、3个月、6个月）对应于“非常早期”（3个月）， “平均”（12个月）和“晚期”（2年）斜视手术， 孩子 为这个项目产生的三个假设， 常见的预测是，眼睛的重新排列越早， 恢复得越好。 资助NIH / NEI $38，505 12/01/98 - 2002年11月30日出版物无P51 RR 00165 -38 1998年1月1日至1998年12月31日Yerkes 区域灵长类研究中心

The long term goal of this research is to reveal the neural mechanisms that explain each of the behavioral deficits of infantile strabismus (eye misalignment), and the time in development at which they occur. The specific goal of the project is to determine if eye realignment early in the critical period can repair these behavioral and structural deficits of visual cortex. Newborn macaques will be reared wearing Dr. Bradley's goggles designed for monkeys, which will be fitted with prism lenses in order to induce optical strabismus. The strabismus will be repaired at one of three postnatal ages (3 weeks, 3 months, 6 months) corresponding to "very early" (3 months), "average" (12 months), and "late" (2 years) strabismus surgery in children. The three hypotheses generated for this project have in common the prediction that the earlier the realignment of the eyes, the greater the recovery. FUNDING NIH / NEI $38,505 12/01/98 - 11/30/02 PUBLICATIONS None P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center