AIDS THERAPIES

由于SIVmne和HIV在结构、基因组组织和疾病产生方面的相似性，SIV模型（体外和体内）非常适合测试HIV药物疗法。 该项目的目标是开发一种有效的抗病毒疗法，以预防或治疗猕猴艾滋病。 最终，这些信息可能会应用于人类艾滋病。 1997年，我们继续进行了一项临床试验，在长尾猕猴中使用无环核苷膦酸盐（R）-9-（2-膦酰甲氧基乙基）腺嘌呤（PMPA）进行暴露前和暴露后预防，以对抗急性SIV感染。 PMPA防止建立SIV感染时，28天的治疗开始后24小时静脉注射病毒接种SIV（100%感染剂量）。 所有未经处理的接种猕猴都感染了SIV。

The SIV model (both in vitro and in vivo) is excellent for testing HIV drug therapies owing to the similarities between SIVmne and HIV in structure, genomic organization, and disease production. The goal of this project is to develop an effective antiviral therapy to either prevent or cure AIDS in macaques. Ultimately, this information may be applied to AIDS in humans. In 1997 we continued a clinical trial using preexposure and postexposure prophylaxis of an acyclic nucleoside phosphonate, (R)-9-(2-phosphonylmethoxyethl)adenine (PMPA), against acute SIV infection in longtailed macaques. PMPA prevented the establishment of SIV infection when a 28-day treatment was initiated 24 h after intravenous virus inoculation with SIV (100% infectious dose). All untreated, inoculated macaques became infected with SIV.