CORE--DATA COLLECTION, MANAGEMENT, AND ANALYSIS

数据收集、管理和分析核心（Data Core）有两个主要目标：1)启动和维持不孕症队列，2)为项目研究者提供技术专长和支持。不孕症队列将包括620对夫妇，他们将在湾区选定的不孕症诊所进行首次咨询访问。队列成员将在任何ART尝试之前、首次ART尝试之后以及6个月、12个月和18个月的随访期间接受访谈。与启动和维持不孕症队列相关的Data Core的职责包括受试者招募、登记和跟踪；对采访者和病历摘录人员进行培训；安排和进行主题访谈；进行医疗记录审查并创建克隆和编辑的数据库。数据中心还将以仪器开发和测试、数据收集以及初级和次级数据分析的形式向项目调查人员提供技术专长和支持。其中三个项目将使用不孕症队列作为主要数据来源；所有四个拟议项目都有概念上的联系，需要重叠的与数据有关的咨询资源，所有项目都有重叠的技术专门知识和支助需要。将资源集中到一个中央单位中，通过允许项目获得更大范围的人力和其他资源，并通过创建一个允许最大限度协作努力的基础设施，将丰富拟议的研究。数据中心将由一名主任、担任专业人员的主要研究人员和共享研究人员组成。专业人员在确保项目成功的必要领域展示了专业知识，包括相关的科学领域，与跨学科团队进行合作研究，项目项目和中心资助的经验，与不孕症提供者和工作人员的成功合作历史，以及与不孕症患者的接触，以及模范的领导经验。

The Core for Data Collection, Management, and Analysis (Data Core) has two primary objectives: 1) to initiate and maintain the Infertility Cohort, and 2) to provide technical expertise and support to project investigators. The Infertility Cohort will include 620 couples who are seen for an initial consultation visit at selected infertility practices in the Bay Area. Cohort Members will be interviewed prior to any ART attempts, following the initial ART attempt, and at 6, 12, and 18 month follow-ups. Responsibilities of the Data Core related to initiating and maintain the Infertility Cohort include subject recruitment, enrollment and tracking; training of interviewers and medical record abstractors; scheduling and conducting subject interviews; conducting medical record reviews and creation of a cloned and edited database. The Data ore will also provide technical expertise and support to project investigators in the form of instrument development and testing, data collection, and analysis of primary and secondary data. Three of the projects included in the program project will use the Infertility Cohort as its primary data source; all four of the proposed projects have conceptual linkages requiring overlapping data-related consultative resources, and all of the projects have overlapping technical expertise and support needs. Pooling resources into a central unit will enrich the proposed research by allowing projects access to a greater range of human and other resources, and by creating an infrastructure that will allow for maximum collaborative effort. The Data Core will be staffed by a Director, principal investigators who serve as professional personnel, and shared research personnel. Professional staff have demonstrated expertise in the areas necessary to ensure project success, including the scientific areas of relevance, the conduct of collaborative research with interdisciplinary teams, experience with program projects and center grants, a history of successful collaboration with infertility providers and staff and access to infertile patients, and exemplary leadership experience.