A PHASE II/III STUDY OF SNX-111 FOR NONMALIGNANT PAIN

SNX-111(IND#45718)是一种电压敏感型钙通道阻滞剂， 特异性阻断神经元(N型)钙通道。这些渠道 在脑组织的胶状质中密度最高 背角，在那里钙离子内流的阻断已经被证明创造了 止痛药。本研究旨在评估该药的安全性和安全性 鞘内注射SNX-111缓解慢性非恶性病变的可行性 疼痛。药物将通过临时鞘内导管/外部泵输送 或者，在以前使用过设备的患者中。

SNX-111 (IND#45718) is a voltage-sensitive calcium channel blocker that specifically blocks neuronal (N-type) calcium channels. These channels are found in highest density within the substantia gelatinosa of the dorsal horn, where blockade of calcium influx has been shown to create analgesia. The present study is designed to assess the safety and feasibility of intrathecal SNX-111 in relieving chronic, nonmalignant pain. Drug will be delivered via temp.intrathecal catheter/external pump or, in patients with previous device.