TECHNIQUE FOR DETERMINATION OF CARDIAC OUTPUT DURING HEAVY EXERCISE

在过去的一年里，我们已经开始了侵入性研究，将新开发的开路技术与直接Fick方法进行了比较。在1998年，我们通过不同强度的锻炼，包括最大限度的锻炼，在休息时进行了其中4项研究。这项研究的初步结果已提交给美国运动医学院。尽管这些研究具有侵入性，但并没有出现任何问题。我们的计划是再测试两名受试者，很可能在1999年冬季和春季完成研究。这项研究的结果非常有希望，可能会对GCRC目前使用的非侵入性技术做出重大贡献，并可能为随后提交的关于运动期间通风和灌流匹配的赠款提供额外的初步数据。由于几个原因，为这项研究招募的几名受试者没有完成所有课程。其中包括1名受试者因怀孕，1名受试者因最近诊断的医疗问题，1名受试者因离开诊所到斯科茨代尔进行医疗轮换，1名受试者不愿进行侵入性研究。每个受试者都要进行一次最初的最大运动测试，一次是比较两种非侵入性心输出量技术的测试，另一次是比较开路技术和菲克技术的最终测试。

Over the last year, we have started the invasive studies comparing the newly developed open circuit technique to the direct Fick method. During 1998, we performed 4 of these studies during rest through various intensities of exercise, including maximal exercise. The preliminary results of the study have resulted in an abstract submission to the American College of Sports Medicine. Despite the invasive nature of the studies, there have been no problems. Our plans are to test 2 additional subjects, likely completing the studies during the winter and spring of 1999. The results of the study are quite promising and will likely contribute significantly to the non-invasive techniques currently used in the GCRC and may provide additional preliminary data for a subsequent grant submission concerning ventilation and perfusion matching during exercise. Several subjects recruited for the study did not complete all of the sessions for several reasons. These included 1 subject due to pregnancy, 1 due to a recently diagnosed medical concern, 1 subject due to leaving the clinic to perform medical rotations at Scottsdale and 1 subject preferred not to perform the invasive study. Each subject performs an initial maximal exercise test, a test to compare two non-invasive cardiac output techniques and a final test comparing the open circuit technique to the Fick technique.