COMPARATIVE BACKBONE DYNAMICS OF NTRC IN ITS ACTIVE & INACTIVE CONFORMATIONS

该项目的主要目标是：确定代谢 人类泌尿上皮细胞的能力，用于激活 4-氨基联苯及其N-羟基代谢物。 识别哪个 近似代谢物被转化为活性亲电子物质。 鉴定由DNA与DNA的相互作用产生的DNA加合物。 DNA的终极亲电体 评估生物效应 4-氨基联苯衍生物与尿路上皮DNA的相互作用 （A）突变水平和（B）肿瘤转化水平。

The major goal of this project is to: Determine the metabolic capabilities of the human uroepithelial cells, for activation of 4-aminobiphenyl and its N-hydroxy metabolites. Identify which of the proximate metabolites are converted to reactive electrophilic species. Identify the DNA-adducts that are generated by interaction of the ultimate electrophile with the DNA. Evaluate the biological effects of interaction of 4-aminobiphenyl derivatives with urothelial DNA - at the level of (A) mutation and (B) neoplastic transformation.