NATIONAL STABLE ISOTOPE RESOURCE AT LOS ALAMOS

我们建议继续运行国家稳定同位素 洛斯阿拉莫斯国家实验室的资源(先生)。主要目标是 SIR的目的是促进碳同位素的新应用 (12C，13C0，氧(12O，17O，18O)，氮(14N，15N)，硫(32S， 33S、34S、36S)和较小程度的硒(77Se)溶解 生物化学、生物物理学以及实践中的基本问题 医学上的问题。该提案的研究部分 建议为特定的标签制定有效的程序 氨基酸、核酸、酶辅因子和新的起始材料 用于合成。通过向研究提供这些材料 社区，资源将对基础研究做出贡献 蛋白质和核酸的结构，蛋白质和核酸的相互作用， 以及血红素蛋白中的结构-功能关系。资源将 继续实施一系列核心、服务、协作和 旨在扩大#年稳定同位素用途的培训活动 生物医学研究。它将继续为发展作出贡献。 设计高效的稳定同位素标记化合物的商业化 将标记的CO和NO转化为有用材料的程序。 成为资源活动重点的特定化合物将 在与资源咨询委员会协商后进行选择，并 将在竞争的基础上提供给外部调查人员。这个 后者是The Resources最重要的服务之一。

We propose to continue the operation of a national stable isotope resource (SIR) at the Los Alamos National Laboratory. The principal goal of the SIR is to promote new applications for the isotopes of carbon (12C, 13C0, oxygen (12O, 17O, 18O), nitrogen (14N, 15N), sulfur (32S, 33S, 34S, 36S), and to a lesser degree selenium (77Se) in solving fundamental problems in biochemistry, biophysics, as well as practical problems in medical science. The research component of the proposal suggests development of efficient procedures for specific labeling of amino acids, nucleic acids, enzyme cofactors, and new starting materials for syntheses. By making these materials available to the research community, the Resource will contribute to fundamental studies of protein and nucleic acid structure, protein-nucleic acid interactions, and structure-function relations in heme proteins. The Resource will continue to carry out a spectrum of core, service, collaborative, and training activities aimed at broadening the uses for stable isotopes in biomedical research. It will continue its contribution to the developing commerce in stable isotopically labeled compounds by devising efficient procedures for converting labeled CO and NO to useful materials. Particular compounds that become the focus of Resource activities will be selected in consultation with the Resource's Advisory Committee and will be provided to external investigators on a competitive basis. The latter is one of the most important services of the Resource.