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AMBISOME COMPARED WITH AMPHOTERICIN B FOR HISTOPLASMOSIS IN AIDS PTS

AMBISOME COMPARED WITH AMPHOTERICIN B FOR HISTOPLASMOSIS IN AIDS PTS
Ambisome 与两性霉素 B 治疗艾滋病患者组织胞浆菌病的比较
批准号：
6121106
负责人：
PHILIP C JOHNSON
金额：
$1.51万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6121106
关键词：
AIDS AIDS therapy amphotericin B clinical research combination chemotherapy drug screening /evaluation histoplasmosis human subject human therapy evaluation microorganism disease chemotherapy opportunistic infections

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中文摘要
翻译
本研究的目的是比较AmBisome作为诱导疗法治疗艾滋病患者中重度播散性组织胞浆菌病的效果。患者将随机接受静脉注射AmBisome或两性霉素B两周的诱导治疗。然后患者将接受伊曲康唑额外10周的巩固治疗，以完成12周的疗程。这是真菌研究小组的一项多中心研究。约翰逊博士是这项全国性研究的首席研究员。该研究已达到75人，并将很快进行分析。
英文摘要
The aim of this studyis to compare AmBisome as induction therapy for the treatment of moderate to severe disseminated histoplasmosis in patients with AIDS. Patients will be randomized between treatment with IV AmBisome or amphotericin B for two weeks of induction therapy. Patients will then be treated with itraconazole for 10 additional weeks of consolidation therapy to complete a 12 week treatment course. This is a multicenter study of the Mycoses Study Group. Dr. Johnson is the PI for this nationwide study. The study has reached its total enrollment of 75 and will be analyzed soon.
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