BONE MINERAL DENSITY--INFLUENCE OF AGE AND RACE

无论男女，骨量都随着年龄的增长而减少。影响骨质流失的因素包括年龄、性别以及种族。非裔美国男性和女性的骨质流失速度比白人男性和女性慢。骨密度扫描已成为测量骨质流失的“金标准”，但它并没有充分解决老龄化人群中骨质减少的性别差异。此外，非洲裔美国人与白种人骨质流失率的比较还没有得到充分的研究。本研究的目的是将两个解剖部位的骨密度（BMD）与24个月的非裔美国人和白种人老年人群以及绝经后妇女的血清和尿液骨骼更替标志物联系起来。在本报告期间，对最后5例患者进行了研究。整个研究的结果表明，虽然DEXA扫描可能是分期骨质流失的金标准，但尿液标志物脱氧吡啶啉似乎是动态骨质流失的最具信息量的生物标志物。血清标志物骨钙素和前胶原I型羧基末端肽与种族和性别缺乏相关性。由于本研究的入组人数有限（总共70人），研究结果无法确定按年龄、性别和种族分层的多个亚组之间有统计学意义的差异。该结果确实证实了先前观察到的非裔美国人研究人群中骨量较高，骨质流失率较低。

Bone mass decreases with increasing age in both men and women. Factors that influence the rate of bone loss include age and gender, as well as race. Bone loss in African American men and women is slower than in Caucasian men and women. Bone density scans, which have become the "gold standard" for measuring bone loss, have not adequately addressed gender- based differences in osteopenia in an aging population. Furthermore, the comparison of African American bone loss rates with those of Caucasians has not received adequate study. The goal of this protocol is to correlate bone mineral density (BMD) at two anatomical sites with serum and urine markers of skeletal turnover over a period of 24 months in a population of aging African American and Caucasian men and postmenopausal women. During this reporting period, the final five patients were studied. The results of the entire study indicate that while DEXA scans may be the gold standard for staging bone loss, the urinary marker deoxypyridinoline appears to be the most informative biomarker for dynamic bone loss. The serum markers osteocalcin and procollagen type I carboxyl terminal peptide exhibited a lack of correlation with ethnicity and gender. Because of limited enrollment in this study (70 total), the results lack the power to define statistically meaningful differences between the multiple subgroups stratified by age, gender and ethnicity. The results do confirm previous observations of higher bone mass and reduced rate of bone loss in the African American study population.