HUMAN SMALL INTESTINAL MOTILITY AND TRANSPORT--CORRELATIVE STUDIES

在临床上，肠道整合了运输和运动功能，以提供对各种挑战的协调反应。本研究的目的是1)通过同时测量正常志愿者的参数来确定肠上皮运输与运动性之间的关系，以及2)确定电缆分析测量肠中渗透性的替代电阻的可行性。为了做到这一点，研究人员设计了一根管子来测量小肠的运动（压力）和运输。在被招募的志愿者中，我们已经证明了同时测量运动和电致运输的可行性。葡萄糖浓度的增加引起电位差信号的增加。运动模式与迁移运动复合体的三个阶段相一致。有趣的是，直接将葡萄糖注入空肠并不会导致进食模式的逆转。由于一名患者的胆碱能副作用，我们决定停止使用乙酰胆碱作为分泌刺激，现在将使用前列腺素类似物。

Clinically, the intestine integrates transport and motility functions to provide a coordinated response to a variety of challenges. The goals of this study are 1) to determine the relationship between intestinal epithelial transport and motility by measuring parameters simultaneously in normal volunteers, and 2) to determine the feasibility of cable analysis to measure electrical resistance, a surrogate for permeability, in the intestine. To accomplish this, the investigators designed a tube to measure small bowel motility (pressure) and transport. In the volunteers enrolled, we have demonstrated the feasibility of these simultaneous measurements of motility and electrogenic transport. Increasing concentrations of glucose elicit an increasing potential difference signal. Motility patterns are consistent with the three phases of the migrating motor complex. Interestingly, direct installation of glucose into the jejunum does not cause reversion to a fed pattern. Because of cholinergic side effects in one patient, we have decided to stop using acetyl choline as a secretory stimulus and will now use prostaglandin analogues.