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INTERFERON A--PROLONGATION OR PERMANENCE OF THE HONEYMOON PERIOD IN DIABETES

INTERFERON A--PROLONGATION OR PERMANENCE OF THE HONEYMOON PERIOD IN DIABETES
干扰素 A——糖尿病蜜月期的延长或持久
批准号：
6121138
负责人：
STALEY armstrong BROD
金额：
$1.51万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6121138
关键词：
clinical research clinical trial phase I diabetes mellitus therapy human subject human therapy evaluation immunotherapy insulin dependent diabetes mellitus interferon alpha oral administration pancreatic islet function

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中文摘要
翻译
这是一项在胰岛素依赖型糖尿病（一种自身免疫性疾病）中摄入干扰素-α（IFN-α）的I-II期试验。 研究IFN-α对IDDM患者免疫功能和β细胞功能的影响。 将入组新诊断的IDDM受试者，治疗期长达12个月。 通过摄入IFN-α建立临床改善或免疫抑制可能导致安慰剂对照的II-III期试验，其中临床疾病的持续改善作为主要结局。
英文摘要
This is a phase I-II trial of ingested interferon-alpha (IFN-a) in insulin dependent diabetes mellitus (IDDM), an autoimmune disease. It will study the effect of IFN-a on immune function and Beta cell function and destruction in IDDM. Subjects with newly diagnosed IDDM will be enrolled for a treatment period of up to 12 months. Establishment of clinical improvement or immunosuppression with ingested IFN-a may lead to a placebo-controlled phase II-III trial with persistent improvement in clinical disease as a primary outcome.
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会议论文
IFNA: PROLONGATION OR PERMANENCE OF THE "HONEYMOON" PHASE IN DIABETES MELLITUS
PREVENTION OF COGNITIVE DECLINE IN ALZHEIMER'S DISEASE VIA INGESTED IFN-ALPHA
PROTEIN BIOMARKERS OF IFN-ALPHA IN MS
INGESTED IFN-A: PROLONGATION OR PERMANENCE OF THE "HONEYMOON" PHASE IN DIABETES
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