CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE

这五年中心更新建立在我们的神经生物学主题 通过检查病理生理学和治疗， 可卡因和艾滋病神经毒性。 该中心的项目范围从临床前 与阿片类药物相关的人类实验室和临床试验 和可卡因依赖，以及艾滋病毒感染。 近5年 我们有超过50个出版物，10个独立的新赠款， 7个项目的进展情况。 我们现在制定了六个新的重大项目， 本中心更新其中四个是以前项目的延伸：1。 下丘脑-垂体-肾上腺轴与可卡因的神经行为效应，2。 糖皮质 依赖性函数，3。 SPECT和微透析测量 可卡因滥用，4，拉莫三嗪用于HIV+患者的可卡因滥用。 两个新 项目已经从我们的试点工作和与双方的合作， 综合医学临床研究中心和艾滋病临床试验单位 耶鲁大学：5。 阿米洛利治疗冠心病相关性脑灌注不足， 6. 阿片类药物依赖对艾滋病抗病毒治疗的影响 药物治疗 核心小组将继续支持与这些组织的合作， 耶鲁大学的其他研究中心，以整合整个中心的主要 项目和调查员，每年进行2-3次试点研究， 重点关注艾滋病相关治疗和神经生物学。 这些试点包括 接受美沙酮治疗的早期艾滋病患者的皮质醇水平， 神经影像学检查在艾滋病认知障碍患者中的应用

This five year Center renewal builds on the neurobiology THEME of our previous nine years by examining the pathophysiology and treatment of cocaine and AIDS neurotoxicity. The Center projects range from preclinical neurobiology to human laboratory and clinical trials relevant to opioids and cocaine dependence, as well as HIV infection. During the last 5 years we have over 50 publications, 10 independent new grants, and substantial progress on all 7 projects. We now developed six new Major Projects for this Center renewal of which four are extensions of previous projects: 1. The HPA Axis and Neurobehavioral Effects of Cocaine, 2. Glucocorticoid Function in Cocaine Dependence, 3. SPECT and Microdialysis Measurements of Cocaine Abuse, 4,Lamotrigine for Cocaine Abuse in HIV+Patients. Two new projects have evolved from our pilot work and collaborations with both the General Medical Clinical Research Center and the AIDS Clinical Trials Unit at Yale: 5. Amiloride for Cocaine Associated Cerebral Perfusion Deficits, 6. Opiate Dependence Pharmacotherapy Effects on AIDS Antiviral medications. The CORE will continue to support collaborations with these other research Centers at Yale, to integrate across the Center's Major Projects and investigators, and to conduct 2-3 pilot studies per year with a focus on AIDS related treatments and neurobiology. These pilots include cortisol levels in early AIDS patients on methadone treatment and neuroimaging in AIDS patients with cognitive impairment.