NEURAL SYSTEMS--RETRIEVAL OF CONCRETE ENTITIES/ACTION WORDS IN BRAIN DAMAGED PTS

不同概念实体的词提取缺陷患者 类别或用于动作，仍然能够检索许多词汇表 物品。因此，问题就产生了，哪些神经结构允许这样做 “残留”字词检索，这是一个重要的问题 我们对语言处理的神经基础的理解，并 阐明脑可塑性在脑康复中的作用机制 受伤。在本项目中，我们将测试以下三种替代方案 假设：(1)残差词提取依赖于激活 右半球的区域，与大脑半球中激活的区域同源 正常英语受试者的左半球；(2)残余区 能力与紧邻的解剖环境中的激活相关 或(3)残词检索所依赖的 右半球同源基因的激活和大脑周围的 受损区域。我们将在四个PET中研究40个脑损伤对象 实验涉及检索表示具体实体的单词， 以及表示行动的词语。这个项目的证据将是 对了解颅脑损伤后的康复过程具有重要价值 英语失语症患者，以及ASL失语症患者，以及 设计有效的康复策略。

Patients with word retrieval defects for entities from varied conceptual categories or for actions, are still capable of retrieving many lexical items. The question thus arises as to which neural structures permit this "residual" word retrieval, a question that is important both to further our understanding of the neural basis of language processing, and to elucidate mechanisms of brain plasticity in the recovery from brain injury. In this project we will test the following three alternative hypotheses: (1) that residual word retrieval depends on the activation of regions in the right hemisphere, homologous to the ones activated in the left hemisphere in normal English speaking subjects; (2) that the residual capacity correlates with activation in the immediate anatomical surround of the damaged area; or (3) that the residual word retrieval depends on both activation of the right hemisphere homologues and the surround of the damaged area. We will study 40 brain damaged subjects in four PET experiments, involving the retrieval of words denoting concrete entities, as well as words denoting actions. Evidence from this project will be of great value to understand the process of recovery from brain injury in patients with English aphasia, as well as those with ASL aphasia, and to design effective rehabilitation strategies.