CORE--CLINICAL

临床核心促进了MADRC的目标， 通过识别男性来满足个人项目的需求， 和患有神经退行性疾病的女性， 对老年痴呆症感兴趣并适合 参与临床研究。 卫星 位于底特律的诊断和治疗中心（SDTC） 在密歇根州北方的农村地区， 城乡居民主体的多样性， 反映疾病严重程度的全范围， 症状严重受损。 潜在研究 受试者，包括通过 老年医学研究和培训中心 密歇根州，给予全面的医疗和神经 检查和分类使用明确的诊断， 入选和排除标准。 人口数据和 神经系统疾病的症状和体征，包括 行为、运动体征和痴呆严重程度， 在每个诊所使用标准化程序进行表征 访问 这些被试中的一个子集， 健康决定的授权书，并表明一个愿望 进行尸检， 作为研究临床过程的资源 疾病和临床病理相关性。 他们收到 在整个过程中定期进行临床评价， 他们的疾病包括行为的定量评估 和电机标志，并经常通过电话联系， 并提供社会工作和护理服务， 继续合作。 核心人员为患者和护理人员提供支持， 鼓励患者参与研究， 家属合作获取死后脑组织 考试 他们协调和监督 患者参与临床研究， 适当的受试者选择和患者安全， 进行了多项研究。 内核还协调 其活动与地方，州和国家方案， 阿尔茨海默病，如CERAD。 临床中心还提供有关临床 痴呆症和患者评估和管理方面 项目和其他核心的MADRC和批准 其他资助项目。 核心工作人员还 进行关于医生作用的介绍， 社会工作者和护士在诊断，评估， 治疗和管理痴呆症的教育和 MADRC的推广效果。

The Clinical Core promotes the goals of the MADRC and serves the needs of individual projects by identifying men and women with neurodegenerative diseases associated with dementia who are interested in and appropriate to participate in clinical research studies. Satellite Diagnostic and Treatment Centers (SDTC) located in Detroit and in rural northern Michigan help achieve an ethnically diverse population of rural and urban residing subjects who reflect the full range of disease severity from minimally symptomatic to severely impaired. Potential research subjects, including normal controls identified through the Geriatric Research and Training Center at the University of michigan, are given comprehensive medical and neurological examinations and classified using explicit diagnostic, inclusion and exclusion criteria. Demographic data and the signs and symptoms of their neurological disease, including behavior, motor signs and dementia severity, are characterized using standardized procedures at each clinic visit. A subset of these subjects who have named a durable power of attorney for health decisions and indicate a wish to obtain an autopsy are followed longitudinally and serve as a resource for studies examining the clinical course of disease and clinicopathological correlations. They receive periodic clinical evaluations throughout the course of their illness including quantitative assessment of behavior and motor signs, and are contacted frequently by telephone, and furnished social work and nursing services to encourage continued cooperation. Core personnel provide patient and caregiver support that stimulates patient participation in research, and the cooperation of families in obtaining postmortem brain examinations. They coordinate and oversee the participation of patients in clinical research to assure appropriate subject selection and patient safety when multiple studies are performed. The Core also coordinates its activities with local, state and national programs for Alzheimer's disease, such as CERAD. The Clinical Core also provides consultation about clinical aspects of dementia and patient evaluation and management to projects and other cores of the MADRC and to approved projects with other funding. The staff of the Core also conducts presentations concerning the role of physicians, social workers, and nurses in the diagnosis, assessment, treatment and management of dementia for educational and outreach effects of the MADRC.